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Blockade of Eph/ephrin interactions does not inhibit fibrinogen binding to αIIbβ3. The binding of labeled fibrinogen to platelets activated with ADP was measured by flow cytometry in the presence or absence of His-EphA4 plus His-EphB1 (10 μg/ml of each). The results shown compare resting with stimulated platelets and are representative of five such experiments.
