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Model of FOG-1–GATA factor interaction requirements during megakaryocyte development. During an early stage of megakaryocyte commitment, FOG-1 requires an interaction with either GATA-1 or GATA-2. During a later stage, FOG-1 specifically requires an interaction with GATA-1. GATA-2 also plays a role in proliferation of progenitor cells (indicated by looping arrow). F1, FOG-1; G1, GATA-1; G2, GATA-2.
