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. 2025 Jul 17;16:1557972. doi: 10.3389/fmicb.2025.1557972

FIGURE 7.

Network diagram illustrating interactions between metabolites and microbiota. Orange circles represent metabolites, while blue triangles depict microbiota. Red and blue lines indicate relationships between them, reflecting complex interconnections.

Correlation network analysis between the 62 differential metabolites involved in the 10 significantly altered metabolic pathways in the PA groups (as shown in Table 2) and the 15 differentially enriched gut bacterial genera (as shown in Figure 3B). Differential metabolites (depicted as orange circles) and differentially enriched gut bacterial genera (represented as blue triangles) are visualized as nodes. The size of each node represents its degree, reflecting the number of connections to other nodes within the network. The lines connecting these nodes represent statistically significant Spearman correlation coefficients (with p < 0.05 and |coefficient| > 0.7). Specifically, red links signify positive interactions between nodes, whereas blue links denote negative interactions.