TABLE 3.
The differential metabolites between PA and HC groups involved in the 10 metabolic pathways, with impact value > 0.1 and p < 0.05.
| Pathway description | Impact value | p-value | Hits | Metabolite | PA vs. HC |
| Tyrosine metabolism | 0.376106797 | 1.43346E-08 | 14 | P-Coumaric Acid | Down |
| Vanillylmandelic acid | Down | ||||
| Norepinephrine | Down | ||||
| 2-(4-Hydroxyphenyl)ethanol | Down | ||||
| 3,4-dihydroxyphenylacetic Acid | Down | ||||
| Tyrosol | Down | ||||
| L-Tyrosine | Down | ||||
| Gentisate Aldehyde | Down | ||||
| 4-Hydroxyphenylacetaldehyde | Down | ||||
| Vanylglycol | Down | ||||
| Homogentisic acid | Down | ||||
| Gentisic acid | Down | ||||
| 4-Hydroxyphenylpyruvic acid | Down | ||||
| Succinic acid | Down | ||||
| Phenylalanine, tyrosine and tryptophan biosynthesis | 0.349533716 | 4.24383E-07 | 10 | Chorismate | Down |
| Phenylpyruvic acid | Down | ||||
| 2,4-Dihydroxybenzoic acid | Down | ||||
| Quinic acid | Down | ||||
| L-Tyrosine | Down | ||||
| 5-Dehydroquinic acid | Down | ||||
| Shikimic acid | Down | ||||
| 4-Hydroxyphenylpyruvic acid | Down | ||||
| Protocatechuic acid | Down | ||||
| 3-Hydroxybenzoic acid | Down | ||||
| Valine, leucine and isoleucine biosynthesis | 0.302352941 | 0.000468321 | 5 | (S)-2-Acetolactate | Down |
| (S)-2-Aceto-2-hydroxybutanoic acid | Down | ||||
| 2-Isopropylmalic acid | Down | ||||
| 3-Isopropylmalic acid | Down | ||||
| 2-Isopropyl-3-oxosuccinate | Down | ||||
| Glycerophospholipid metabolism | 0.199687695 | 0.015201736 | 8 | PG(16:1(9Z)/16:1(9Z)) | Up |
| LysoPC(P-18:0/0:0) | Down | ||||
| PG(i-13:0/18:2(9Z,11Z)) | Up | ||||
| PE(16:0/14:1(9Z)) | Up | ||||
| PE(18:3(6Z,9Z,12Z)/P-18:1(9Z)) | Down | ||||
| PC(14:0/P-18:1(9Z)) | Down | ||||
| Hydroxyclomipramine | Down | ||||
| PA(10:0/i-12:0) | Down | ||||
| Pantothenate and CoA biosynthesis | 0.191680043 | 0.038561865 | 3 | (S)-2-Acetolactate | Down |
| Pantetheine 4’-phosphate | Down | ||||
| 2-dehydropantoate | Down | ||||
| Alpha-linolenic acid metabolism | 0.168814433 | 0.010143705 | 4 | Jasmonic acid | Down |
| 9-Oxo-nonanoic acid | Down | ||||
| PC(14:0/P-18:1(9Z)) | Down | ||||
| 13(S)-Hydroperoxylinolenic acid | Down | ||||
| Steroid hormone biosynthesis | 0.168152441 | 0.003831455 | 7 | Androstenedione | Down |
| Estrone | Up | ||||
| Dihydrocortisol | Up | ||||
| Estrone glucuronide | Up | ||||
| 16b-Hydroxyestrone | Down | ||||
| 3a,21-Dihydroxy-5b-pregnane-11,20-dione | Up | ||||
| 21-Hydroxypregnenolone | Down | ||||
| Tryptophan metabolism | 0.167868039 | 0.005131416 | 7 | 5-Hydroxyindoleacetic acid | Down |
| 5-Methoxyindoleacetate | Down | ||||
| 5-Hydroxyindoleacetate | Down | ||||
| Quinoline-4,8-diol | Down | ||||
| 5-Hydroxy-L-tryptophan | Up | ||||
| 2-Aminomuconic acid semialdehyde | Down | ||||
| L-Kynurenine | Up | ||||
| Ubiquinone and other terpenoid-quinone biosynthesis | 0.165608612 | 0.000555599 | 8 | Chorismate | Down |
| Isochorismate | Down | ||||
| P-Coumaric acid | Down | ||||
| (1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate | Down | ||||
| L-Tyrosine | Down | ||||
| Homogentisic acid | Down | ||||
| 4-Hydroxyphenylpyruvic acid | Down | ||||
| Withanolide B | Up | ||||
| Phenylalanine metabolism | 0.126690482 | 3.51415E-06 | 9 | Phenylpyruvic acid | Down |
| M-Coumaric acid | Down | ||||
| N-Acetyl-L-phenylalanine | Down | ||||
| Phenylacetylglycine | Up | ||||
| L-Tyrosine | Down | ||||
| Phenylacetic acid | Down | ||||
| Hydrocinnamic acid | Down | ||||
| L-3-Phenyllactic acid | Down | ||||
| Succinic acid | Down |