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PLOS One logoLink to PLOS One
. 2025 Jul 31;20(7):e0329495. doi: 10.1371/journal.pone.0329495

Smartphone dependence, addiction, and insomnia among medical students during the COVID-19 pandemic

Virgilio E Failoc-Rojas 1,2, Alicia Torres-Mera 3, Darwin A León-Figueroa 4,5, David Lira 6, Flor M Santander-Hernández 7, Miguel A Guevara-Morales 7, Cristian Díaz-Vélez 8, Mario J Valladares-Garrido 9,*
Editor: Pavle Randjelovic,10
PMCID: PMC12312953  PMID: 40743114

Abstract

Introduction

During the COVID-19 pandemic, smartphone use among students increased, even before going to sleep, which resulted in an increased risk of dependence, addiction, and sleep problems such as insomnia and daytime somnolence. The objective of this study was to determine the association between different levels of problematic smartphone use (dependence and addiction) and insomnia among medical students. In this study, “dependence” refers to subclinical, yet compulsive, smartphone use, while “addiction” denotes a more severe behavioral disruption involving loss of control and functional impairment.

Materials and methods

This was a secondary cross-sectional study of a cohort of medical students from Piura (Peru) during the COVID-19 pandemic in 2020. The study included 370 participants. Insomnia was assessed using the Insomnia Severity Index, and the extent of smartphone use was determined using the Smartphone Dependence and Addiction Scale. A chi-squared test was used for the bivariate analysis, and prevalence ratios (PR) were estimated using Poisson regression with crude and adjusted models and 95% confidence intervals (CI).

Results

Insomnia was reported by 67.8% of participants. Smartphone dependence was identified in 67.8% of students, and 10.8% met the criteria for addiction. The prevalence of insomnia was notably higher among students aged ≥26 years (80.0%) and among those with symptoms of depression (79.3%) and anxiety (81.9%). After adjusting for potential confounders, students classified as dependent were 1.43 times more likely to report insomnia (aPR: 1.43; 95% CI: 1.10–1.86), while those classified as addicted showed an even higher association (aPR: 1.66; 95% CI: 1.26–2.17), compared to nondependent users.

Conclusion

Both smartphone dependence and addiction were significantly associated with a higher prevalence of insomnia among medical students. These findings highlight the need for preventive strategies targeting problematic smartphone use to promote better sleep health in academic settings.

Introduction

Over the last decade, smartphones have become a means of communication, entertainment, and productivity, thus becoming indispensable in our daily lives [1]. More than 5 billion (63.5%) people use the internet worldwide, and 92% of them access the internet from a smartphone [2]. As of 2021, approximately 89% of the Peruvian population aged ≥6 years has used a mobile phone, and 88.5% access the internet through a smartphone [3].

During the COVID-19 pandemic, quarantine was one of the effective measures used by Peru and other states to control the spread of the virus [4]. These restrictive measures could have increased some psychological disorders such as depression, anxiety, anguish, and suicidal thoughts, as well as several sleep problems such as insomnia [5,6]. With the closure of educational institutions, e-learning was developed at a national level, and students used computers, tablets, smartphones, or other devices to access e-learning materials [7,8]. Smartphone use increased by up to 57.2% among university students during the quarantine [9].

Because of the changes in the learning method and their lifestyle, medical students showed an increase in the use of smartphones and the internet, even at night; this increased the risk of addiction or dependence among these students [10]. Previous studies have shown that over 50% of medical students may exhibit smartphone addiction [10,11].

Excessive use of smartphones could generate the need to constantly check the news, stay connected with friends, ‘not miss anything,’ and seek approval from others, leading to constant restlessness, feelings of loneliness, and low self-esteem [12,13]. In addition, excessive use of smartphones before going to sleep has been associated with poor sleep quality, less rest, worsening insomnia, and daytime somnolence [14]; this adversely affects the quality of life [15]. As a consequence, up to 43% of students often experience a lack of energy, and 30% may develop unhealthy habits, such as less exercise, eating fast food, and weight gain. Moreover, their academic performance may decrease by up to 25% [16]. All of the above has been associated with stress (OR = 2.39; p < 0.003), anxiety symptoms (OR = 2.04; p < 0.001), and depression (OR = 2.29; p < 0.001) [17].

Several studies have reported that excessive use of smartphones can affect physical and mental health, primarily associated with musculoskeletal pain and insomnia [18]. Long hours of smartphone use lead to poor posture, which can result in cervical spine injuries and neck pain [18,19], as well as carpal tunnel syndrome [20]. In addition, individuals with smartphone addiction are exposed to a higher risk of accidents (OR = 1.9, 95% CI: 1.26–2.86), such as falls, slips, or collisions, due to being engrossed in smartphone use and not paying attention to their surroundings when performing activities like crossing the street or using the subway [21].

Medicine is one of the most stressful fields of study in university education [22,23]. Thus, the health of medical students is a matter of interest. There have been reports of a relationship between smartphone addiction and sleep quality [24]. Although the association between smartphone dependence and addiction and insomnia was reported before [25] and during the COVID-19 pandemic [11,26], there is little conclusive evidence in medical students, particularly at the Latin American level [27]. In our study, we adopted the framework of the Smartphone Dependence and Addiction Scale (SDAS), which categorizes problematic smartphone use into two increasing severity levels: dependence and addiction. Dependence involves compulsive but still manageable usage, whereas addiction reflects a more intense behavioral disruption marked by impaired control and interference with daily functioning [28]. Previous studies have been conducted with a small number of participants [25]; furthermore, they used instruments to assess only the quality of sleep and changes thereof [11,26], thus preventing the assessment of insomnia among participants and the use of statistical methods to determine a better association.

Moreover, other studies have not measured mental health variables such as depression and anxiety [11,26], which are associated with insomnia and smartphone use [29,30]. In this study, we determined whether smartphone dependence and addiction were associated with insomnia among medical students during the COVID-19 pandemic and whether they were influenced by other variables such as depression, anxiety, and nutritional status. Therefore, we will provide evidence that can help develop interventions to regulate smartphone use, aimed at improving students’ sleep quality and reducing the impact on their academic life.

Materials and methods

Study design and setting

We conducted a cross-sectional analytical study based on secondary data among medical students in Piura, Peru, during the COVID-19 pandemic [30]. This research is a secondary analysis of data originally collected for a previously published study on smartphone overuse, depression, and anxiety (Santander-Hernández et al., 2022). Unlike the original publication, the present work addresses a distinct research question by evaluating smartphone dependence and addiction—as defined by SDAS cutoffs—as the main exposure and insomnia as the primary outcome. This cross-sectional survey was carried out from July to October 2020, coinciding with Peru’s first wave of the pandemic and the implementation of strict social distancing measures, including restrictions on public spaces and limited walking hours. Universities fully transitioned to online learning platforms for medical education, and students attended virtual lectures during the study period.

A convenience sampling strategy was used, contacting the class presidents of each university to estimate the total number of students. Three universities were selected for this study, all of which offer the human medicine program in the Piura region, one of the most affected areas in terms of COVID-19 morbidity and mortality in Peru. These universities were selected based on their availability and willingness to participate, and no specific sampling strategy was used to select them. Surveys were designed using Google Forms and distributed through invitation messages in WhatsApp groups commonly used by students. While this method allowed broad dissemination, it may have affected response rates, which are further discussed in the analysis section. Measures were implemented to avoid duplicate responses, and incomplete surveys were excluded from the analysis.

All information was stored in anonymized databases. After completing the survey, we invited all medical students at the three universities to participate in educational sessions provided by psychiatrists. These sessions were held to thank participants and universities for their support of the investigation and contribute to the prevention of excessive smartphone use among medical students.

Universe, population, and sample: Selection criteria

The target population included all enrolled medical students, regardless of academic year, from the primary study [30]. The sample included 370 students from three universities, representing 16.6% of the population. Specifically, 151 students were from the first university, 121 from the second, and 98 from the third. The selection criterion was that medical students should have a smartphone with internet access for daily use. We excluded participants who had a doctor’s diagnosis of depression or anxiety or who had been treated with antidepressants or anxiolytics in the previous year. A total of 38 participants were excluded due to a history of depression or anxiety, resulting in the final sample size.

Instruments

Insomnia Severity Index (ISI): ISI was developed by Bastien et al. [31] to quantify the severity of perceived insomnia according to the DSM-IV criteria. It is a 7-point self-report instrument rated on a 5-point Likert scale (from 0 = not at all to 4 = extremely). Overall scores range from 0 to 28. The severity of insomnia was classified as clinically unimportant (0–7 points), subthreshold (8–14 points), moderate (15–21 points), or severe (22–28 points). We used a Spanish version [32] of ISI, which was validated in medical students and their social networks. Cronbach’s alpha coefficient in the Spanish sample was 0.82 [32], whereas it was 0.87 in the present investigation.

Smartphone Dependence and Addiction Scale (SDAS): It is a 40-item self-report instrument rated on a 5-point Likert scale (0 = strongly disagree, 1 = disagree, 2 = neither agree nor disagree, 3 = agree, and 4 = strongly agree). SDAS was developed by Aranda-López et al. [28] to evaluate smartphone use in a specific Spanish-speaking population. The scale is divided into three components: (1) use, abuse, and addiction of the smartphone and its applications (30 items); (2) personality traits (6 items); and (3) expenditure on mobile applications and games (4 items). Overall scores range from 0 to 160, and higher scores indicate a higher dependence on smartphones. In our study, we used the cutoff points proposed by the original developers of the scale: nondependence (mean score ≤ 2.23), dependence (2.24–3.05), and addiction (≥ 3.06) [28]. These thresholds were based on terciles calculated during the original validation study and refer to the mean score per item, not the total score [28]. Thus, they are fixed and independent of our sample distribution. Cronbach’s alpha coefficient in the original sample was 0.81, 0.76, and 0.71 for components 1, 2, and 3, respectively [28]. In this investigation, Cronbach’s alpha coefficient was 0.93 for the global scale and 0.93, 0.71, and 0.76 for components 1, 2, and 3, respectively.

In this study, smartphone use was classified into three categories: nondependence, dependence, and addiction, based on severity. While dependence reflects problematic but still functional use, addiction denotes a more severe level, marked by loss of control and functional impairment.

Patient Health Questionnaire-9 (PHQ-9): The PHQ-9 was developed by Kroenke et al. [33] to identify major depression according to DSM-IV criteria and provides total scores from 0 to 27. It is a 9-item self-report questionnaire using a 4-point Likert scale (0 = never, 1 = several days, 2 = more than half the days, and 3 = almost every day). Symptom severity is categorized as minimal (0–4), mild (5–9), moderate (10–14), moderately severe (15–19), and severe (20–27). For analysis, we dichotomized the variable into two categories: participants with scores of 0–4 were considered as having no depression, and those with scores of 5 or more were categorized as having depressive symptoms. For this study, we used a Colombian version of the PHQ-9 [34], which has been validated in medical students with similar characteristics to our study population and with a Cronbach’s alpha coefficient of 0.83, which was 0.91 in our sample.

The General Anxiety Disorder Scale-7 (GAD-7) is a 7-item self-report instrument, using a 4-point Likert scale, designed to assess anxiety symptoms. For anxiety, severity of symptoms was categorized as minimal (0–4), mild (5–9), moderate (10–14), and severe (15–21). Similarly, the anxiety variable was divided into two categories for analysis: participants with scores of 0–4 were considered not to have anxiety symptoms, while those with scores of 5 or more were categorized as having anxiety symptoms. We used the Spanish version of the GAD-7 [35], which has been validated in the general population, with a Cronbach’s alpha coefficient of 0.94 in the Spanish sample and 0.93 in this study.

Variables

Outcome variable.

In this study, insomnia was considered the outcome variable of interest, which was determined using the Insomnia Severity Index (ISI) and operationally defined as a total score greater than 7 points.

Variable exposure.

The total score on the Smartphone Dependence and Addiction Scale (SDAS) ranges from 0 to 160, where higher scores reflect greater levels of smartphone use. In this study, participants were classified using fixed cutoff points established in the original validation of the scale, based on the mean score per item: nondependence (≤2.23), dependence (2.24–3.05), and addiction (≥3.06) [28]. These categories reflect increasing severity of problematic smartphone use and are independent of the sample distribution.

In this study, the term “smartphone” referred to mobile devices with internet access and apps for social networking, messaging, education, or entertainment, all of which may influence usage patterns and potential addiction [36]. Smartphone dependence is a behavioral disorder that involves compulsive use of the device, affecting daily activities, relationships, and health. Sufferers feel anxious or irritable when without the phone and experience a constant need to check it. Although they try to control their use, they often fail. This behavior shares similarities with substance use disorders, reflecting profound psychological and social implications [37].

Secondary independent variables.

Depressive symptoms were defined operationally as a score greater than 4 points, obtained from the sum of responses to the 9 items of the Patient Health Questionnaire-9 (PHQ-9). Participants with a total score of 0–4 were considered not to have depressive symptoms, while those with a score greater than 4 were categorized as having depressive symptoms.

The anxiety variable was defined operationally as a score greater than 4 points, obtained from the sum of responses to the 7 items of the Generalized Anxiety Disorder Scale-7 (GAD-7). Participants with a total score of 0–4 were considered not to have anxiety symptoms, while those with a score greater than 4 were categorized as having anxiety symptoms.

Age was assessed through self-report, and participants provided their exact age, which was then categorized into the following groups: 16–20 years, 21–25 years, and ≥26 years. Sex was also self-reported by the participants. Marital status was recorded based on self-report, with participants indicating whether they were single or in a relationship (e.g., married, cohabiting, or dating). Information on whether a family member had died due to COVID-19 was self-reported by the participants. Nutritional status was measured using self-reported weight and height, from which Body Mass Index (BMI) was calculated. Based on the BMI, participants were categorized into two groups: normal weight and overweight/obese, following standard BMI classifications.

Data analysis

Statistical analysis was performed using Stata v. 16.1 (S1 Table). Variables of interest were initially described with frequencies (n, %). For analysis, an ISI score >8 points was defined as the presence of insomnia. Therefore, the variables followed a dichotomous distribution (0 = absence, 1 = presence) to facilitate the interpretation for decision-making. Bivariate analyses were performed using chi-squared tests to statistically compare the rate of presence of insomnia by covariates. Generalized linear models with a Poisson distribution, log link function, and robust variance were used to determine the association between insomnia and dependence on and addiction to smartphone use. A multivariate analysis was conducted after adjusting for possible confounding factors (age, sex, marital status, body mass index, family member who died of COVID-19, depression, and anxiety). Prevalence ratios (PR) and 95% confidence intervals (CI) were reported. The significance level was set at 5%. To ensure model convergence and allow the estimation of prevalence ratios (PR), robust variance was used in the Poisson regression. This approach was employed to account for potential correlations and heteroscedasticity in the data.

Ethical considerations and participant protection

This study was approved by the Research Ethics Committee of César Vallejo University, Piura, Peru (102P-CEI-EPM-UCV-2020). All participants provided virtual informed consent before proceeding with the survey. This was achieved through a consent form embedded at the beginning of the online questionnaire. Participants were required to read and agree to the consent terms before accessing the survey questions. For participants who were minors, consent was also obtained from their parents or legal guardians prior to their participation. We followed the ethical principles listed in the Declaration of Helsinki.

Data was used exclusively for research purposes and kept confidential. To address potential emotional distress related to sensitive questions, we carefully explained these items to participants before starting the survey. Additionally, the survey was anonymous, and participants were informed that they could withdraw at any time without providing a reason.

Educational sessions were conducted for all participating students after completing the survey, as their responses remained anonymous. At the end of the survey, participants were provided with a link to resources on emotional support, prevention of negative emotional states, and contact information for local mental health centers. Participation was entirely voluntary, and no monetary compensation or academic credit was provided. Responding to the survey had no influence on students’ grades, course evaluations, or academic standing.

Results

Approximately 370 students were included in the study. Most participants were women (61.9%) between 16 and 20 years of age (56.8%). Only a small proportion of participants reported the death of a family member because of COVID-19 (25.4%), and a larger proportion reported experiencing symptoms of depression (78.4%) and anxiety (68.9%). A total of 78.6% of participants were classified as having some level of problematic smartphone use, with 67.8% presenting dependence and 10.8% reaching the threshold for addiction, based on the SDAS scoring system. These categories represent increasing severity, with addiction reflecting a more disruptive pattern of use compared to dependence. Finally, 67.8% of participants reported experiencing symptoms of insomnia classified according to ISI. Table 1 shows the characteristics of the population evaluated in this study.

Table 1. Description of medical students during the COVID-19 pandemic (n = 370).

Characteristics Frequency Percentage
Age (years)
 16–20 210 56.8
 21–25 135 36.5
  ≥ 26 25 6.8
Sex
 Male 141 38.1
 Female 229 61.9
Marital status
 Married or in a relationship 363 98.1
 Single 7 1.9
Family member deceased because of COVID-19
 Yes 94 25.4
 No 276 74.6
Depression
 Yes 290 78.4
 No 80 21.6
Anxiety
 Yes 255 68.9
 No 115 31.1
Nutritional status
 Normal 242 65.4
 Overweight/Obese 128 34.6
Insomnia
 Yes 251 67.8
 No 119 32.2
Dependence on smartphones
 No 79 21.4
 Dependent 251 67.8
 Addiction 40 10.8

The prevalence of insomnia among participants in this study varied by age, with the highest percentage of insomnia occurring among participants aged ≥26 years (80.0%). There were no significant differences in the prevalence of insomnia between men (70.9%) and women (65.9%) (p = 0.319). The prevalence of insomnia was similar between participants who reported the death of a family member because of COVID-19 (63.8%) and those who did not (69.2%) (p = 0.335). However, there were significant differences in the prevalence of insomnia among participants who reported experiencing symptoms of depression (79.3%) and those who did not (26.3%) (p < 0.001) and among participants who reported experiencing symptoms of anxiety (81.9%) and those who did not (36.5%) (p < 0.001). The prevalence of insomnia was higher among participants who were classified as smartphone-dependent (72.1%) than among those who were not (38.0%) (p < 0.001) (Table 2).

Table 2. Factors associated with insomnia among medical students during the COVID-19 pandemic (n = 370).

Characteristics Insomnia (ISI) χ² p
Yes No
Frequency Percentage Frequency Percentage
Age (years) 1.926 0.382
 16–20 142 67.8 68 32.2
 21–25 89 65.9 46 34.1
  ≥ 26 20 80.0 5 20.0
Sex 0.993 0.319
 Male 100 70.9 41 29.1
 Female 151 65.9 78 34.1
Family member deceased because of COVID-19 0.928 0.335
 Yes 60 63.8 34 36.2
 No 191 69.2 85 30.8
Depression 80.911 <0.001
 Yes 230 79.3 60 20.7
 No 21 26.3 59 73.7
Anxiety 75.002 <0.001
 Yes 209 81.9 46 18.1
 No 42 36.5 73 63.5
Nutritional status 0.951 0.329
 Normal 160 66.1 82 33.9
 Overweight/obese 91 71.1 37 28.9
Marital status 0.042 0.837
 Married or in a relationship 246 67.8 117 32.2
 Single 5 71.4 2 28.6
Dependence on smartphones 53.356 <0.001
 No 30 38.0 49 62.0
 Dependent 181 72.1 70 27.9
 Addiction 40 100.0 0 0.0

χ², Chi-squared test

ISI: Insomnia Severity Index

The results indicated that the prevalence of insomnia was significantly higher among individuals with problematic smartphone use. Those classified with dependence were associated with a 1.43-fold higher prevalence of insomnia (aPR: 1.43; 95% CI: 1.10–1.86; p = 0.008), while those categorized as addicted were associated with a 1.66-fold higher prevalence (aPR: 1.66; 95% CI: 1.26–2.17; p < 0.001), compared to nondependent users. This pattern suggests an association gradient, where greater severity of smartphone use corresponds to a higher likelihood of insomnia. The results also indicated that sex (female), normal nutritional status, and being in a relationship were not significantly associated with insomnia. Additionally, there were no statistically significant differences in insomnia prevalence between individuals aged 21–25 years or ≥26 years compared to those aged 16–20 years (Table 3).

Table 3. Crude and adjusted association between smartphone use and insomnia among medical students during the COVID-19 pandemic (n = 370).

Characteristics Simple analysis Adjusted analysis
cPR 95% CI P aPR 95% CI p
Age (years)
 16–20 Ref. Ref.
 21–25 0.97 0.84–1.14 0.746 0.98 0.85–1.13 0.739
  ≥ 26 1.18 0.95–1.47 0.130 1.09 0.89–1.33 0.400
Sex
 Male Ref. Ref.
 Female 0.93 0.81–1.07 0.311 0.95 0.84–1.07 0.739
Family member deceased because of COVID-19
 No Ref. Ref.
 Yes 0.92 0.78–1.09 0.356 0.97 0.83–1.13 0.679
Depression
 No Ref. Ref.
 Yes 3.02 2.08–4.38 <0.001 2.10 1.41–3.12 <0.001
Anxiety
 No Ref. Ref.
 Yes 2.24 1.75–2.88 <0.001 1.48 1.15–1.90 0.002
Nutritional status
 Normal Ref. Ref.
 Overweight/obese 1.08 0.93–1.24 0.319 0.97 0.83–1.13 0.679
Marital status
 Married or in a relationship Ref. Ref.
 Single 0.95 0.59–1.52 0.828 0.94 0.83–1.13 0.679
Dependence on smartphones
 No Ref. Ref.
 Dependent 1.9 1.42–2.54 <0.001 1.43 1.10–1.86 0.008
 Addiction 2.63 1.98–3.49 <0.001 1.66 1.26–2.17 <0.001

cPR, Crude Prevalence Ratio; aPR, Adjusted Prevalence Ratio.

p-values obtained via generalized linear models with Poisson family and robust variance. 95% CI: 95% confidence interval.

Note: Categories are based on fixed mean score cutoffs from the original SDAS validation: nondependence (≤2.23), dependence (2.24–3.05), and addiction (≥3.06).

Discussion

Prevalence of insomnia among medical students

Of the students, 67.8% reported insomnia during the first wave of the COVID-19 pandemic. However, this differs from that reported in Saudi Arabia by Alrashed et al. [38]. In 2021, they reported a prevalence of insomnia of 34.9% among medical students during the COVID-19 pandemic [38]. In 2022, a study in Saudi Arabia reported that 41% of students had a prevalence of moderate to severe insomnia during the COVID-19 pandemic [39]. A multinational study conducted in 2021 during the COVID-19 pandemic by Tahir et al. reported that 73.5% of medical students from the Dominican Republic, Egypt, Guyana, India, Mexico, Pakistan, and Sudan had insomnia [40]. Another study conducted by Pallares et al. in Colombia during the COVID-19 pandemic reported that 60.2% of students from the School of Health Sciences had symptoms of insomnia [41]. In 2023, Allende-Rayme et al. reported that, during the COVID-19 pandemic, 90.48% of medical students from a Peruvian university had insomnia [42]. Other results were reported in 2021. Olarte-Durand et al. concluded that 83.9% of medical students at a private university in Peru had insomnia [43]. This could be explained by the fact that confinement, quarantine, and mobility limitations because of COVID-19 had immediate and inevitable negative effects that significantly altered daily schedules and routines. This led to a virtual adaptation of education, leading to an increased use of smartphones and changes in sleep habits and patterns (in terms of wake-up times, bedtimes, and sleep hours), which are connected to circadian rhythms that regulate sleep; this subjected medical students to insufficient sleep [39,44]. Smartphones emit blue light, which can suppress the production of melatonin—a hormone that helps regulate sleep and circadian cycles [45]. Exposure to blue light at night can delay sleep onset and alter sleep quality, which can contribute to insomnia [46].

Association between smartphone dependence and addiction and insomnia

Smartphone dependence was associated with a 43% higher prevalence of insomnia, while smartphone addiction showed an even stronger association, with a 66% higher prevalence. These findings reflect a severity gradient in which addiction represents a more advanced stage of problematic smartphone use compared to dependence, as categorized by the SDAS.

In 2022, similar results were reported by Liu et al., who found a strong association between smartphone dependence and insomnia (r = 0.566) among medical students from China during the COVID-19 pandemic [10]. In 2021, a study conducted in Indonesia by Indrakusuma et al. also found that smartphone dependence among medical students had a weak positive correlation (r = 0.162) with the prevalence of insomnia during the COVID-19 pandemic [47]. In 2021, during the COVID-19 pandemic in India, Telgote et al. reported a significant correlation (r = 0.35) between smartphone addiction and insomnia severity among medical students [48]. In 2021, Alageel et al. conducted a prepandemic study and reported smartphone dependence among graduate students, who were approximately twice as likely to experience insomnia (odds ratio [OR] = 2.113) [49]. This association could be explained by the increase in the use of smartphones owing to the development of virtual education during the COVID-19 pandemic. This leads to medical students spending more time searching for information on the internet and having unhealthy sleep habits [50]. Thus, prolonged use of smartphones negatively affects the body’s circadian rhythm, which results in insomnia [51].

These findings reinforce existing literature on the relationship between smartphone dependence and insomnia among medical students. However, our study adds value by focusing on a Latin American population, where such associations remain underexplored. Unlike previous studies conducted primarily in Asia and the Middle East [10,47–49], our research captures the unique academic and socioeconomic stressors experienced by medical students in Peru during the COVID-19 pandemic. Additionally, by quantifying the increased prevalence of insomnia associated with smartphone dependence, we provide empirical evidence that supports the urgent need for interventions targeting digital health literacy and responsible smartphone use among future healthcare professionals.

It is important to note that the categorization of smartphone use levels was based on fixed thresholds established in the original validation of the SDAS, not on sample-derived percentiles. This methodological choice ensures comparability with other studies using the same instrument and strengthens the external validity of our findings.

Other factors associated with insomnia

In our study, depression was associated with a higher prevalence of insomnia. This is like what was reported in China in 2023 by Zhang et al., who showed a higher prevalence of insomnia among medical students with depression (OR = 2.12) [52]. In 2021, Choi et al. reported in the Republic of Korea that the prevalence of insomnia symptoms was significantly higher among participants with symptoms of depression than in those without said symptoms (64.7% vs. 8.3%, respectively; p < 0.001) [53]. In 2021, Liu et al. showed that depression among Chinese medical students was positively correlated with insomnia (r = 0.679, p < 0.001) [54]. In 2022, Copaja-Corzo et al. reported a significant association between symptoms of insomnia and depression among Peruvian medical students (adjusted PR [aPR] = 2.03) [55]. In Saudi Arabia, Alrashed et al. reported in 2021 that medical students with severe depression had a higher probability of reporting experiencing symptoms of insomnia (OR = 3.10) [38]. Medical students are at a high risk of developing depression symptoms because of the stress associated with their education, including psychological and academic factors [56,57]. This leads to changes in their biological clock and alterations in the production of sleep-regulating hormones, such as melatonin; consequently, the ability to fall asleep and maintain sleep can become impaired, thus causing insomnia [57].

Anxiety was associated with a higher prevalence of insomnia among the population in our study. This is like what was reported in Norway by Haugland et al. [58]. In 2021, they concluded that students with anxiety symptoms were at a higher risk of developing insomnia (RR = 1.03) [58]. In 2023, Zhang et al. reported in China that the probability of developing insomnia increased among medical students with anxiety (OR = 2.35) [52]. In Pakistan, Mahmood-ul-Hassan et al. reported in 2021 that medical and nonmedical students showed a statistically significant correlation between anxiety scores and insomnia scores (r = 0.742) [59]. In Taiwan, Chen et al. reported in 2022 that medical students with anxiety had more symptoms of insomnia (β = 0.51, p < 0.001) [60]. In Peru, Copaja-Corzo et al. reported in 2021 that the prevalence of insomnia increased by 48% among medical students with anxiety (aPR = 1.48) [55]. In 2022, Olarte-Durand et al. reported that male Peruvian medical students with anxiety had increased symptoms of insomnia (aPR = 1.34) [43]. This relationship could be explained by diverse factors associated with the academic environment and lifestyle of medical students [61]. The accumulation of academic hours, intense study demands, and exposure to emotionally challenging courses can lead to considerable levels of anxiety among students. This can have negative effects, such as sleep deprivation and disruption of the circadian rhythm, which, in turn, can lead to insomnia [62].

Implications of the findings in medical education

Because of the COVID-19 pandemic, rigorous control measures, such as social distancing, were implemented worldwide. This situation caused an adaptation of online medical education, thus leading to an addiction to smartphones among medical students [26,57,58,62]. Smartphone use has become increasingly common and has transformed the way we interact and communicate. However, smartphone addiction is an emerging public health issue with several causes contributing to its prevalence, including social, psychological, technological, and familial aspects [63]. Nevertheless, the COVID-19 pandemic was the most crucial factor that influenced the level of smartphone addiction [64].

Exposure to artificial light from smartphones and other electronic devices before going to sleep can interfere with the body’s natural circadian rhythm, making it more difficult to fall asleep and affecting sleep quality [65]. This can lead to a decline in cognitive and physical performance, thus affecting people’s ability to work and perform daily activities effectively [66].

Beyond individual health consequences, the high prevalence of insomnia among medical students due to excessive smartphone use raises concerns about its long-term impact on academic performance, cognitive function, and professional readiness. Sleep deprivation can impair learning, decision-making, and clinical reasoning skills, all of which are crucial in medical education and future clinical practice [67]. Addressing these issues through institutional policies—such as curriculum-integrated education on sleep hygiene, time management, and digital well-being—could enhance both academic success and long-term professional competency in healthcare settings.

In our investigation, we discovered a direct and significant relationship between smartphone addiction and the presence of insomnia. Moreover, medical students’ use of smartphones before going to sleep affected their sleep quality and ability to fall asleep, which could lead to the development of chronic sleep problems. These health issues could negatively affect the quality of life, academic performance, learning ability, and memory of medical students [67].

Considering the findings, it is crucial to expand education on smartphone dependence to all healthcare providers. Screening for smartphone addiction should become a routine practice, particularly when addressing sleep disorders or cognitive decline, as early identification can help prevent the negative impacts on sleep quality, academic performance, and overall health. Raising awareness among medical students about the risks of excessive smartphone use, especially before bedtime, can play a pivotal role in mitigating these effects and promoting healthier sleep habits [68,69].

To further support this initiative, integrating education on smartphone addiction and its health implications into medical curricula is essential. Our study contributes by specifically focusing on medical students in Piura, a region in northern Peru, during the COVID-19 pandemic, providing valuable insights into the unique challenges faced by this population. Standardizing this content across medical schools will ensure that future healthcare professionals are well-equipped to recognize and address the issue in both themselves and their patients [70]. By focusing on this under-researched cohort, particularly within the context of remote learning, our study offers a detailed examination of how pandemic-related changes have exacerbated smartphone addiction and related health issues. This comprehensive approach will contribute to better management of technology-related sleep disorders and foster healthier lifestyles for both medical students and the wider population [71].

Additionally, our findings emphasize the need for medical schools to implement proactive strategies, such as digital detox programs and structured sleep hygiene workshops. Given that excessive smartphone use before bedtime is linked to cognitive impairment and reduced academic performance, institutions should consider integrating mandatory well-being modules to help students develop healthier technology habits. Future research should explore the effectiveness of such interventions in reducing insomnia and improving academic outcomes among medical students.

Limitations and strengths

This study has several limitations. First, the use of an online survey for data collection may have introduced selection bias, as medical students who frequently use social media and the internet may have been more likely to participate. This could potentially overestimate the association between smartphone addiction and insomnia if students with higher technology use were more inclined to report sleep disturbances; conversely, students who experience insomnia but do not engage frequently with online platforms may have been underrepresented, leading to a possible underestimation of the true prevalence.

Second, the findings may not be fully generalizable to the broader medical student population, as the data were collected from a single region of Peru, introducing potential selection bias. The cultural, educational, and socioeconomic factors unique to this setting may limit the extrapolation of our results to other regions or countries. Future studies should consider multi-center designs to enhance external validity. Although we used a convenience sampling strategy and data collection was conducted via WhatsApp groups, the demographic characteristics of our sample—particularly regarding age and sex—are consistent with those reported in recent multicenter mental health studies conducted among Peruvian medical students during the COVID-19 pandemic [72–75]. This comparability suggests that, despite the non-probabilistic nature of our sampling, the findings may still reflect broader patterns within this population. Third, certain variables that could influence both smartphone addiction and sleep patterns were not included in our analysis due to data availability constraints; these included total daily study hours [76], monthly family income [77], physical activity [78], healthy eating habits [79], average sleep duration [77], academic year [49], and academic performance [80]. The omission of these factors may introduce residual confounding, and future research should integrate a more comprehensive set of predictors. Additionally, further studies should explore the frequency, duration, and type of social media applications used [81], the impact of online gaming [82], the presence of suicidal thoughts [83], chronic illnesses [84], and smartphone use during different times of the day [55].

Fourth, our sample consisted exclusively of medical students, which limits the ability to compare smartphone addiction and insomnia across different academic disciplines. Given that study demands and stress levels may vary significantly between fields, comparative research including students from other disciplines is warranted to determine whether these associations are specific to medical students or represent a broader phenomenon [50].

Despite these limitations, our study provides important contributions to literature. To our knowledge, this is the first study from Latin America to examine the association between smartphone dependence and insomnia among medical students, particularly in the context of the COVID-19 pandemic. We used validated instruments to assess key psychological and behavioral factors, ensuring robust data quality. Furthermore, our analysis was conducted using rigorous biostatistical methods to minimize bias and enhance internal validity.

Relevance of mental health findings

Our findings lay the foundation for the future in this field. Potential areas for further investigation include (1) longitudinal studies assessing the progression of smartphone dependence and addiction and insomnia among medical students; (2) comparative studies evaluating differences between medical students and other university populations; (3) research exploring the effect of smartphone use on sleep quality by differentiating users and non-users; (4) analyses examining the relationship between smartphone use, addiction, and insomnia in relation to academic performance; and (5) studies investigating the interplay between physical activity, smartphone addiction, and sleep disturbances.

By addressing these gaps, future research can contribute to the development of targeted interventions aimed at mitigating the adverse effects of excessive smartphone use on sleep and mental health among medical students. Moreover, our study highlights the importance of understanding smartphone dependence not only as an individual behavioral issue but also as a broader academic and institutional concern. Given this context, structured interventions—such as digital well-being education, sleep hygiene programs, or cognitive-behavioral strategies—should be evaluated for their effectiveness in mitigating insomnia and promoting mental health among medical students.

Conclusions

In this cross-sectional study, we found that both smartphone dependence and addiction were significantly associated with a higher prevalence of insomnia among medical students during the COVID-19 pandemic. Additionally, those with anxiety and depression were more likely to report severe insomnia symptoms. These results highlight the importance of raising awareness about the potential risks associated with excessive smartphone use, particularly its association with reduced sleep quality. While causal relationships cannot be established, interventions that address problematic smartphone use may contribute to promoting better sleep hygiene and improving overall well-being.

Our study underscores the pressing need for targeted interventions addressing smartphone dependence among medical students. Medical schools should consider implementing evidence-based guidelines for digital device usage, particularly before bedtime, to promote healthier sleep patterns. Given the well-established link between sleep deprivation and academic underperformance, integrating sleep education and digital detox strategies into medical curricula could help safeguard students’ cognitive and professional development.

Supporting information

S1 Table. Database.

(DTA)

pone.0329495.s001.dta (26KB, dta)
S1 Checklist. STROBE Statement—checklist of items that should be included in reports of observational studies.

(PDF)

pone.0329495.s002.pdf (138.7KB, pdf)

Data Availability

All relevant data are within the paper and its Supporting Information files.

Funding Statement

This research is self-financed. MJV-G was supported by the Fogarty International Center of the National Institutes of Mental Health (NIMH) under Award Number D43TW009343 and the University of California Global Health Institute (UCGHI).

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Decision Letter 0

Juan Luis Castillo-Navarrete

Dear Dr. Valladares-Garrido,

Thank you for submitting your manuscript to PLOS ONE. After careful consideration, we feel that it has merit but does not fully meet PLOS ONE’s publication criteria as it currently stands. Therefore, we invite you to submit a revised version of the manuscript that addresses the points raised during the review process.

==============================

ACADEMIC EDITOR:

Thank you for submitting your manuscript to PLOS ONE. The study addresses a highly relevant topic by exploring smartphone dependence, insomnia, and their association with mental health and behavioral patterns, particularly in the context of medical students during the COVID-19 pandemic. The research design is sound, and the findings provide meaningful insights that contribute to the growing body of literature in this field.

After carefully considering the feedback provided by the reviewers, it is evident that while the comments individually suggest minor adjustments, their cumulative scope indicates the need for a more thorough revision. This decision is not a reflection of any fundamental issues with your work but rather an opportunity to ensure that the manuscript meets the highest standards of clarity, methodological transparency, and interpretative rigor.

We suggest expanding the introduction to include additional literature on behavioral addiction and its relationship with mental health conditions. This will help contextualize the study within the broader research landscape and better articulate the research gap your study aims to address. Highlighting the novelty of your approach and findings will strengthen the manuscript further.

In the methods section, please provide greater detail on the sampling strategy, including the number of universities selected, and elaborate on the exclusion process that led to the final sample size. It would also be helpful to clarify how confounding variables, such as nutritional status, were identified and measured, as well as how the adjustments were applied during the analysis. Additionally, we recommend reorganizing the section to separate the description of scales and instruments from operational definitions, which could be included as a distinct subsection for improved readability.

The ethical considerations require clarification, specifically regarding the type of consent obtained from participants. This information should be included explicitly to align with ethical guidelines and ensure transparency.

In the results section, address the discrepancies between the methods and results regarding the categorization of variables such as depression and anxiety. Additionally, refine the interpretation of prevalence ratios to provide a clearer understanding of the findings.

Finally, the discussion would benefit from a deeper reflection on the implications of your findings in addressing the research gap and contributing to future work in this area. Explicit acknowledgment of the methodological limitations, including potential selection biases and the rationale for excluding certain clinical conditions, will enhance the manuscript’s rigor and balance.

We recognize the effort that has already gone into this study and appreciate its potential to contribute meaningfully to the field. We look forward to receiving your revised manuscript and are confident that these changes will further strengthen the work.

==============================

Please submit your revised manuscript by Feb 22 2025 11:59PM. If you will need more time than this to complete your revisions, please reply to this message or contact the journal office at plosone@plos.org . When you're ready to submit your revision, log on to https://www.editorialmanager.com/pone/ and select the 'Submissions Needing Revision' folder to locate your manuscript file.

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We look forward to receiving your revised manuscript.

Kind regards,

Juan Luis Castillo-Navarrete, Ph.D.

Academic Editor

PLOS ONE

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Reviewers' comments:

Reviewer's Responses to Questions

Comments to the Author

1. Is the manuscript technically sound, and do the data support the conclusions?

Reviewer #1: Yes

Reviewer #2: Yes

Reviewer #3: Yes

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2. Has the statistical analysis been performed appropriately and rigorously? -->?>

Reviewer #1: Yes

Reviewer #2: Yes

Reviewer #3: Yes

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3. Have the authors made all data underlying the findings in their manuscript fully available??>

The PLOS Data policy

Reviewer #1: Yes

Reviewer #2: Yes

Reviewer #3: Yes

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4. Is the manuscript presented in an intelligible fashion and written in standard English??>

Reviewer #1: Yes

Reviewer #2: Yes

Reviewer #3: Yes

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Reviewer #1: Please read the attached annotated manuscript for comments. The manuscript details findings on associations between various count data variables, namely, smartphone dependence and insomnia and associated sociodemographic variables. Whilst there is nothing inherently problematic in the manuscript, the amount of new information to the area is adequate. Self-reported student stress and smartphone time consumption are significantly associated but this finding is not novel nor unexecpted. Nonetheless, the research design and statistical analyses is correct and the authors do not move beyond what the data suggests.

Reviewer #2: In the introduction section, authors have mentioned limited literature related to the study, they are suggested to add more on behavioral addiction and smart phone addition and its association with mental health conditions. In method section (line no. 97-100), authors mentioned “we acknowledge the inherent limitations of this method, including the potential for selection bias, which may limit the generalizability of our findings. A discussion of these limitations is provided in the results and discussion sections.” This should only be mentioned in the limitation section of the study.

Line 114 and 115, authors have mentioned that “they excluded people who had a doctor's diagnosis of depression, or who had been treated with antidepressants in the previous year. How about anxiety and other clinical conditions, why only excluding depression. As we know that during pandemic more anxiety was reported then depression, kindly clarify this.

Authors are requested to give description of scales/instruments in subsection separately. They are requested to mention the operational definitions separately at the end of method section, it should not be mixed up with the description of scales/instruments.

Reviewer #3: 1. In Ethics statement, please "indicate the form of consent obtained"

2. Please find the comments for given line numbers below:

Line 95. How many universities were selected? Were all universities in Peru included? If not, what sampling strategy was used?

Line 116. How many participants were included in the survey? And how many were excluded to reach the final sample size of 370?

Line 157. I suppose, 15-19 should be categorized as 'moderately severe' instead of 'moderate'.

Line 164. Details on confounding variables could be elaborated. For example, how was the nutritional status measured? Also, were the assumptions of poisson regression met?

Line 175. How were the confounding variables identified, and how was the minimal set of adjusted confounders determine? (e.g. using DAG or any models)

Line 180. I suppose, the participants provided a written consent.

Line 199. In the methods section, it says that depression was a categorical variable. However, in the results, it is presented as a dichotomous variable. Could you explain how it was dichotomized? Same for anxiety, the methods section does not explain how the variable anxiety was treated.

Line 217. Since you are reporting exp beta, an interpretation like this "The prevalence of insomnia was 1.9 times higher among individuals with smartphone dependence compared to those without dependence" may be better than saying "more likely to" (as it sounds more like interpreting likelihood)

Line 223. Since you are talking about the frequency of insomnia, are you referring to table 2?

**********

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Reviewer #1: No

Reviewer #2: Yes:  Salman Shahzad

Reviewer #3: Yes:  Supriya Sherpa

**********

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Attachment

Submitted filename: PONE-D-24-56765_reviewer1.pdf

pone.0329495.s003.pdf (1.7MB, pdf)
PLoS One. 2025 Jul 31;20(7):e0329495. doi: 10.1371/journal.pone.0329495.r003

Author response to Decision Letter 1


11 Feb 2025

Dear Editor,

Thank you very much for reviewing our article, " Smartphone dependence, addiction, and insomnia among medical students during the COVID-19 pandemic ". Your suggestions and comments will be addressed below. Thank you for your valuable time and excellent review.

Editor's comments

1. Editor says: We suggest expanding the introduction to include additional literature on behavioral addiction and its relationship with mental health conditions. This will help contextualize the study within the broader research landscape and better articulate the research gap your study aims to address. Highlighting the novelty of your approach and findings will strengthen the manuscript further.

Our response: Thank you for your comment. As suggested, the introduction has been expanded with literature on smartphone addiction and its association with anxiety and depression.

2. Editor says: In the methods section, please provide greater detail on the sampling strategy, including the number of universities selected, and elaborate on the exclusion process that led to the final sample size. It would also be helpful to clarify how confounding variables, such as nutritional status, were identified and measured, as well as how the adjustments were applied during the analysis. Additionally, we recommend reorganizing the section to separate the description of scales and instruments from operational definitions, which could be included as a distinct subsection for improved readability.

Our response: Thank you for your insightful comments. We appreciate the opportunity to clarify and enhance the methodology section. We have addressed each point as follows:

a) Ethical considerations (form of consent): We have added more detailed information regarding the form of consent obtained, as follows:

"All participants provided virtual informed consent before proceeding with the survey. This was achieved through a consent form embedded at the beginning of the online questionnaire. Participants were required to read and agree to the consent terms before accessing the survey questions.” (lines 398-416).

b) Sampling strategy and universities selected: Three universities were selected for this study, all offering the human medicine program in the Piura region, one of the most affected areas in terms of COVID-19 morbidity and mortality in Peru. The universities were chosen based on availability and willingness to participate, with no specific sampling strategy. The sampling approach was non-probabilistic and based on convenience, given the logistical constraints posed by the pandemic. This is now clarified in lines 201-207.

c) Exclusion criteria (number of participants excluded): The survey initially included a larger number of participants, but 38 were excluded due to a history of depression or anxiety, diagnosed by a healthcare professional or treated with antidepressants/anxiolytics in the previous year. This resulted in a final sample size of 370 participants. This is now included in lines 198-207.

d) Confounding variables (identification and adjustment): Confounding variables were selected based on prior literature, expert opinion, and known relationships with the outcome variables (insomnia and smartphone dependence/addiction). A stepwise approach was used to determine the minimal set of confounders, including age, sex, marital status, BMI, family member deceased due to COVID-19, depression, and anxiety. These variables were tested for inclusion based on statistical significance. This is now clarified in lines 323-382.

e) Separation of scales/instruments and operational definitions: As requested, we have reorganized the methods section to clearly separate the description of scales from the operational definitions. The description of each instrument (Insomnia Severity Index, Smartphone Dependence and Addiction Scale, PHQ-9, and GAD-7) is now in a separate subsection, with operational definitions of the variables of interest placed at the end of the methods section, as suggested.

We hope these changes address your concerns and improve the clarity and quality of the manuscript.

3. Editor says: The ethical considerations require clarification, specifically regarding the type of consent obtained from participants. This information should be included explicitly to align with ethical guidelines and ensure transparency.

Our response: Thank you for your valuable comment. We appreciate your suggestion to clarify the ethical considerations, particularly regarding the type of consent obtained from participants. In response to this, we have expanded the Ethical Considerations section to provide a more comprehensive description of the consent process.

We now specify that virtual informed consent was obtained from all participants before they proceeded with the survey. The consent process was clearly outlined at the beginning of the online questionnaire, where participants were presented with a detailed consent form. This form included comprehensive information about the study's purpose, procedures, potential risks, confidentiality, and their right to withdraw at any time without consequence. Participants were required to read the consent form carefully and electronically agree to the terms by selecting an option that indicated their consent before gaining access to the survey questions. This method ensured that all participants had a clear understanding of the study and voluntarily agreed to participate.

4. Editor says: In the results section, address the discrepancies between the methods and results regarding the categorization of variables such as depression and anxiety. Additionally, refine the interpretation of prevalence ratios to provide a clearer understanding of the findings.

Our response: Thank you for your insightful comment. We apologize for the oversight in the methods section. To clarify, both depression and anxiety were treated as categorical variables based on symptom severity, as follows:

• Depression: Symptoms were categorized into minimal (0-4), mild (5-9), moderate (10-14), moderately severe (15-19), and severe (20-27). For analysis, we dichotomized it into two categories: no depression (0-4) and depressive symptoms (5+).

• Anxiety: Symptoms were categorized into minimal (0-4), mild (5-9), moderate (10-14), and severe (15-21). Similarly, we dichotomized it into no anxiety (0-4) and anxiety symptoms (5+).

We hope this clarification resolves the discrepancies and improves the interpretation of the results.

5. Editor says: Finally, the discussion would benefit from a deeper reflection on the implications of your findings in addressing the research gap and contributing to future work in this area. Explicit acknowledgment of the methodological limitations, including potential selection biases and the rationale for excluding certain clinical conditions, will enhance the manuscript’s rigor and balance.

Our response:

Thank you for your insightful comments and for the opportunity to improve our manuscript. We appreciate your suggestions regarding the discussion section and have made the following revisions:

• We have expanded our discussion on how our findings address the research gap. Specifically, we highlight how our study provides novel insights into smartphone addiction and insomnia among medical students in Latin America, a population that has been underrepresented in previous research.

• We have further elaborated on how our findings can inform future research by suggesting potential studies that explore causal mechanisms, intervention strategies, and comparative analyses across different student populations.

• We have explicitly acknowledged additional methodological limitations, including a more detailed discussion on potential selection bias due to the online survey format and the rationale for excluding certain clinical conditions.

Reviewer #1:

1. Reviewer says: Please read the attached annotated manuscript for comments. The manuscript details findings on associations between various count data variables, namely, smartphone dependence and insomnia and associated sociodemographic variables. Whilst there is nothing inherently problematic in the manuscript, the amount of new information to the area is adequate.

Our response: Thank you for your valuable feedback. We acknowledge that the associations between smartphone dependence, insomnia, and sociodemographic variables, such as student stress, have been well-documented in the literature. However, we believe that our study provides significant value by focusing on medical students during the pandemic, a population that faced unique challenges related to the rapid transition to online learning, increased mental health burdens, and changes in daily routines. The analytical approach we used allowed us to examine these variables in a comprehensive way, providing insight into the specific impact of the pandemic on this group. Our study also contributes to the existing literature by considering the unique challenges faced by medical students in Piura, a region in northern Peru, especially regarding the transition to remote learning during the COVID-19 pandemic. Additionally, we employed a cross-sectional analytical approach, utilizing validated self-report scales to assess smartphone dependence and insomnia, which allows for a more nuanced understanding of these issues in a specific cohort. While the findings may not be novel, we hope to contribute to a better understanding of these issues and their implications for medical education and student well-being during extraordinary circumstances. Furthermore, we have carefully applied statistical analyses to ensure the data is interpreted in the most accurate and meaningful way possible.

Finally, we have emphasized these points in the Implications of Findings section of the manuscript to highlight the unique context of medical students during the pandemic. Moreover, we recognize the limitations of our study in the Discussion section, acknowledging factors such as the cross-sectional design and the self-reported nature of the data, which may limit the generalizability of the findings.

2. Reviewer says: Self-reported student stress and smartphone time consumption are significantly associated but this finding is not novel nor unexecpted. Nonetheless, the research design and statistical analyses is correct, and the authors do not move beyond what the data suggests.

Our response:

We sincerely appreciate the reviewer’s insightful comments, which have helped us refine our manuscript. In response, we have strengthened the discussion by highlighting our study’s contribution to existing knowledge and its broader implications. Specifically, we have expanded the discussion on how our findings add new empirical evidence from a Latin American population and complement previous studies conducted in other regions.

Please find the revised manuscript attached. We hope the changes meet the reviewer’s expectations.

Reviewer #2:

1. Reviewer says: In the introduction section, authors have mentioned limited literature related to the study, they are suggested to add more on behavioral addiction and smart phone addition and its association with mental health conditions.

Our response: Thank you for your comment. As suggested, I have added literature on smartphone addiction and its association to anxiety and depressive symptoms.

In method section (line no. 97-100), authors mentioned “we acknowledge the inherent limitations of this method, including the potential for selection bias, which may limit the generalizability of our findings. A discussion of these limitations is provided in the results and discussion sections.” This should only be mentioned in the limitation section of the study.

Our response: Thank you for your helpful comment. We apologize for the oversight in the methods section. As suggested, we have removed the mention of selection bias and its potential impact on the generalizability of our findings from the methods section. This information has now been properly included in the limitations section of the manuscript.

2. Reviewer says: Line 114 and 115, authors have mentioned that “they excluded people who had a doctor's diagnosis of depression, or who had been treated with antidepressants in the previous year. How about anxiety and other clinical conditions, why only excluding depression. As we know that during pandemic more anxiety was reported then depression, kindly clarify this.

Our response: Thank you for pointing out this important detail. We apologize for the error in the initial version of the manuscript. In fact, both depression and anxiety were considered exclusion criteria for participation in the study due to their potential impact on the participants' mental health status and the risk of bias in the study outcomes. This has now been clarified and reformulated in lines 115-119 of the methods section.

3. Reviewer says: Authors are requested to give description of scales/instruments in subsection separately. They are requested to mention the operational definitions separately at the end of the method section, it should not be mixed up with the description of scales/instruments.

Our response: We appreciate the reviewer’s observation. As requested, we have reorganized the information in the methods section to clearly separate the description of the scales from the operational definitions. The description of each instrument (Insomnia Severity Index, Smartphone Dependence and Addiction Scale, PHQ-9, and GAD-7) is now located in a separate subsection, while the operational definitions of the variables of interest (insomnia, depressive and anxiety symptoms) have been placed at the end of the methods section, as requested.

Reviewer #3:

1. Reviewer says: 1. In Ethics statement, please "indicate the form of consent obtained"

2. 2. Please find the comments for given line numbers below:

Our response: Thank you for your valuable comment. We have added more detailed information regarding the form of consent obtained as follows: "All participants provided virtual informed consent before proceeding with the survey. This was achieved through a consent form embedded at the beginning of the online questionnaire. Participants were required to read and agree to the consent terms before accessing the survey questions. (lines 398-416).

3. Reviewer says: Line 95. How many universities were selected? Were all universities in Peru included? If not, what sampling strategy was used?

Our response: Thank you for your comment. Three universities were selected for this study, all of which offer the human medicine program in the Piura region, one of the most affected areas in terms of COVID-19 morbidity and mortality in Peru. These universities were selected based on their availability and willingness to participate, and no specific sampling strategy was used to select them.

The sampling approach used for this study was non-probabilistic and based on convenience, which was the most feasible option given the logistical constraints and limitations posed by the pandemic. We acknowledge the potential limitations of this approach, including the possibility of selection bias, which may affect the generalizability of the findings. These limitations are discussed further in the results and discussion sections. This has been included in lines 173-207 of the Methods section.

4. Reviewer says: Line 116. How many participants were included in the survey? And how many were excluded to reach the final sample size of 370?

Our response: The survey included a total of 370 participants, representing a subset of the medical student population across three universities. Of the initial participants, 38 were excluded due to a history of depression/anxiety, either diagnosed by a healthcare professional or having been treated with antidepressants or anxiolytics in the previous year. The final sample size of 370 participants was reached after applying this exclusion criterion. This information is discussed in detail between lines 198-207 of the Methods section.

5. Reviewer says: Line 157. I suppose, 15-19 should be categorized as 'moderately severe' instead of 'moderate'.

Our response: Thank you for your suggestion. We have re

Attachment

Submitted filename: Response to Reviewers.pdf

pone.0329495.s005.pdf (423.4KB, pdf)

Decision Letter 1

Pavle Randjelovic

Dear Dr. Valladares-Garrido,

Thank you for submitting your manuscript to PLOS ONE. After careful consideration, we feel that it has merit but does not fully meet PLOS ONE’s publication criteria as it currently stands. Therefore, we invite you to submit a revised version of the manuscript that addresses the points raised during the review process.

The authors used both the terms dependence and addiction in the text. Somewhere they are distinct and somewhere they are interchanged. I would suggest to change this to avoid confusion and to use only one term or to clearly explain the difference between then in the text.

The SDAS cutoff points are pooled from the sample so they are sample dependent. They don't give absolute numbers which would be more sample independent. I would like to see more explanation abut this. With that kind of cutoff points any sample would produce both addictive and non-addictive participants.

The authors wrote `We found that smartphone dependence increased the prevalence of insomnia by 44.2%.` This result is from chi square test of association, so we can not draw conclusion what is the cause. Maybe it was the other way round or some third factor influencing both of those. The authors should change the language used to describe this result.

Sincerely,

Academic Editor

==============================

Please submit your revised manuscript by Jul 24 2025 11:59PM. If you will need more time than this to complete your revisions, please reply to this message or contact the journal office at plosone@plos.org . When you're ready to submit your revision, log on to https://www.editorialmanager.com/pone/ and select the 'Submissions Needing Revision' folder to locate your manuscript file.

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Reviewers' comments:

Reviewer's Responses to Questions

Comments to the Author

Reviewer #4: All comments have been addressed

**********

2. Is the manuscript technically sound, and do the data support the conclusions??>

Reviewer #4: Yes

**********

3. Has the statistical analysis been performed appropriately and rigorously? -->?>

Reviewer #4: Yes

**********

4. Have the authors made all data underlying the findings in their manuscript fully available??>

The PLOS Data policy

Reviewer #4: Yes

**********

5. Is the manuscript presented in an intelligible fashion and written in standard English??>

Reviewer #4: Yes

**********

Reviewer #4: Thank you for the opportunity to review the manuscript entitled "Smartphone dependence, addiction, and insomnia among medical students during the COVID-19 pandemic" (Manuscript ID: PONE-D-24-56765). The manuscript addresses an important and timely topic, particularly given the global reliance on digital devices and the mental health challenges exacerbated by the COVID-19 pandemic.

Overall Assessment:

The study is well-structured, the statistical analysis is appropriate, and the discussion is grounded in relevant literature. The use of validated instruments (ISI, PHQ-9, GAD-7, and SDAS) strengthens the methodological rigor, and the findings contribute meaningfully to the existing knowledge on smartphone dependence and sleep health in medical student populations.

Strengths:

The large sample size (n = 370) provides adequate power for the analyses.

Adjustments for potential confounders such as depression and anxiety enhance the internal validity of the results.

The study uses a well-defined and operationalized construct of smartphone dependence and addiction using a validated scale adapted for Spanish-speaking populations.

Areas for Improvement:

Clarity on Secondary Analysis:

While the authors mention this is a secondary analysis of previously collected data (ref [21]), greater clarity should be provided regarding the original study’s objectives, overlap in variables analyzed, and the novelty of this manuscript’s specific focus. This is essential to fully assess the extent of original contribution and avoid concerns of salami publication or dual submission.

Sampling and Generalizability:

The convenience sampling strategy and use of WhatsApp groups may limit generalizability. While this is acknowledged in the discussion, it may be helpful to provide more context or comparison with national student demographics to assess representativeness.

Data Availability:

The manuscript states “All relevant data are within the manuscript and its Supporting Information files.” However, it would be helpful to explicitly indicate where the datasets can be accessed or whether any anonymized data files are provided for replication purposes.

Ethical Considerations:

The authors adequately describe IRB approval and informed consent. However, it would strengthen the ethical narrative to specify whether participants were compensated (monetarily or through academic credits) and confirm that participation did not influence course evaluations or academic standing.

Language and Formatting:

A few sections would benefit from minor editorial revisions for clarity and flow, particularly in the Methods and Discussion. For instance, "not single" could be more clearly described as "married or in a relationship."

Future Directions:

While the authors suggest longitudinal and comparative studies in the future, it may be valuable to highlight the potential of interventions (e.g., smartphone use reduction strategies or sleep hygiene programs) that could stem from this evidence.

Ethics and Integrity:

There are no apparent concerns related to research misconduct or unethical practices. The ethics approval is clearly stated (CEI-EPM-UCV-2020), and there is no indication of duplicate publication at this time. However, the authors should ensure that the current manuscript provides distinct contributions relative to the prior publication (ref [21]).

**********

what does this mean? ). If published, this will include your full peer review and any attached files.

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Reviewer #4: Yes:  Carlos Miguel Rios-Gonzalez

**********

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PLoS One. 2025 Jul 31;20(7):e0329495. doi: 10.1371/journal.pone.0329495.r005

Author response to Decision Letter 2


11 Jun 2025

Dear Editor,

Thank you very much for reviewing our article, " Smartphone dependence, addiction, and insomnia among medical students during the COVID-19 pandemic ". Your suggestions and comments will be addressed below. Thank you for your valuable time and excellent review.

Editor's comments

1. Editor says: The authors used both the terms dependence and addiction in the text. Somewhere they are distinct and somewhere they are interchanged. I would suggest to change this to avoid confusion and to use only one term or to clearly explain the difference between then in the text.

Our response: Thank you for your valuable observation regarding the inconsistent use of the terms dependence and addiction throughout the manuscript. We acknowledge that in the previous version, these terms were sometimes used interchangeably and without sufficient conceptual clarification, which could lead to confusion for readers.

In response, we have carefully revised the manuscript to ensure precise and consistent terminology aligned with the structure of the Smartphone Dependence and Addiction Scale (SDAS), the instrument used in this study. This scale classifies smartphone use into three categories—nondependence, dependence, and addiction—based on increasing severity. To clarify this, we have added a concise conceptual distinction in the Materials and Methods section, stating that dependence refers to problematic but still functional smartphone use, whereas addiction denotes a more severe level, marked by loss of control and functional impairment. This clarification has also been echoed in the Introduction, the Abstract, and the Discussion to maintain internal consistency.

Moreover, in the Results section and tables, we have preserved both categories to respect the original scoring structure of the SDAS, using fixed cutoff values (≤2.23, 2.24–3.05, ≥3.06) established during the original validation study. A corresponding explanatory note has also been added to Table 3 to reflect this, and all prior references to sample-based percentiles have been corrected.

2. Editor says: The SDAS cutoff points are pooled from the sample so they are sample dependent. They don't give absolute numbers which would be more sample independent. I would like to see more explanation abut this. With that kind of cutoff points any sample would produce both addictive and non-addictive participants.

Our response: Thank you for the opportunity to clarify this methodological point. We understand the concern regarding the use of percentile-based cutoffs, which would indeed render the classification of smartphone use levels sample-dependent and limit generalizability. However, we would like to clarify that we did not generate cutoffs from our own sample distribution. Instead, we followed the original scoring criteria proposed by Aranda-López et al. (2017) in the development and validation of the “Escala de Dependencia y Adicción al Smartphone (EDAS)”. This validated scale establishes fixed thresholds based on average item scores to classify users into three categories:

• Nondependent use: mean score ≤ 2.23

• Dependent use: mean score between 2.24 and 3.05

• Addictive use: mean score ≥ 3.06

These thresholds were applied directly in our research and therefore do not vary across samples. The categorization in our study is sample-independent and consistent with the instrument’s validated structure. To avoid further confusion, we have revised the Materials and Methods section to explicitly state that the classification was based on predefined, validated cutoff scores from the original scale, and not on percentiles derived from our study sample.

3. Editor says: The authors wrote `We found that smartphone dependence increased the prevalence of insomnia by 44.2%.` This result is from chi square test of association, so we can not draw conclusion what is the cause. Maybe it was the other way round or some third factor influencing both of those. The authors should change the language used to describe this result.

Our response: Thank you for the valuable observation. We have revised the language in the Abstract, Results, and Discussion to ensure that only associations are reported, avoiding any implication of causality. The revised phrasing reflects that smartphone dependence and addiction were associated with higher prevalence of insomnia. We also added a statement in the Discussion and Conclusions acknowledging that the cross-sectional design does not permit causal inference.

4. Editor says: The same applies to `depression increased the prevalence of insomnia`. It is test of association.

Our response: Thank you for the observation. We have revised the language to reflect that depression was associated with a higher prevalence of insomnia, rather than suggesting a causal relationship. This change has been made in the Results and Discussion sections to ensure consistency with the cross-sectional nature of the study.

Reviewer #4:

1. Reviewer says: Thank you for the opportunity to review the manuscript entitled "Smartphone dependence, addiction, and insomnia among medical students during the COVID-19 pandemic" (Manuscript ID: PONE-D-24-56765). The manuscript addresses an important and timely topic, particularly given the global reliance on digital devices and the mental health challenges exacerbated by the COVID-19 pandemic.

Our response: Thank you for your positive feedback and for recognizing the relevance of our study. We appreciate your comments and have addressed them carefully to improve the manuscript.

2. Reviewer says: The study is well-structured, the statistical analysis is appropriate, and the discussion is grounded in relevant literature. The use of validated instruments (ISI, PHQ-9, GAD-7, and SDAS) strengthens the methodological rigor, and the findings contribute meaningfully to the existing knowledge on smartphone dependence and sleep health in medical student populations.

Our response: Thank you for your encouraging remarks. We appreciate your recognition of the study’s structure, methodological rigor, and contribution to the literature.

3. Reviewer says: The large sample size (n = 370) provides adequate power for the analyses. Adjustments for potential confounders such as depression and anxiety enhance the internal validity of the results.

Our response: Thank you for highlighting the strengths of our study design. We appreciate your recognition of the sample size and the inclusion of relevant covariates to improve internal validity.

4. Reviewer says: The study uses a well-defined and operationalized construct of smartphone dependence and addiction using a validated scale adapted for Spanish-speaking populations.

Our response: Thank you for acknowledging the use of a validated and culturally adapted scale. We agree that employing a well-defined construct enhances the robustness and relevance of our findings.

5. Reviewer says: Clarity on Secondary Analysis:

While the authors mention this is a secondary analysis of previously collected data (ref [21]), greater clarity should be provided regarding the original study’s objectives, overlap in variables analyzed, and the novelty of this manuscript’s specific focus. This is essential to fully assess the extent of original contribution and avoid concerns of salami publication or dual submission.

Our response: Thank you for this important observation. We confirm that the current manuscript is a secondary analysis of data originally collected for the study published as reference [21] (Santander-Hernández et al., PLOS ONE, 2022). In that study, the primary objective was to assess the association between smartphone overuse and symptoms of depression and anxiety. In contrast, the present manuscript is based on a different research question, focusing on the role of smartphone dependence and addiction—as defined by validated SDAS cutoffs—as the main exposure, and insomnia as the primary outcome. These variables (exposure and outcome) were not analyzed or reported in the original publication. Therefore, the analytic model, outcome of interest, and conceptual framing are all distinct, providing an original contribution to literature. We have now revised the Methods section to clearly state the objective of the primary study, the overlap in instruments, and the novelty of the present focus. We also confirm that there is no duplication or overlap in results, and that this manuscript addresses a unique and independent line of inquiry.

6. Reviewer says: Sampling and Generalizability:

The convenience sampling strategy and use of WhatsApp groups may limit generalizability. While this is acknowledged in the discussion, it may be helpful to provide more context or comparison with national student demographics to assess representativeness.

Our response: Thank you for this insightful suggestion. We acknowledge that the use of convenience sampling through WhatsApp groups may limit the generalizability of our findings. However, as noted in the revised Discussion section, recent multicenter mental health studies conducted in Peru among medical students during the COVID-19 pandemic have reported demographic characteristics—particularly in terms of age and sex—similar to those observed in our sample [PMID: 35201957, 35967544, 37923417, 37363900]. This comparability supports the representativeness of our sample and adds contextual value to the interpretation and applicability of our results despite the non-random sampling method.

7. Reviewer says: Data Availability:

The manuscript states “All relevant data are within the manuscript and its Supporting Information files.” However, it would be helpful to explicitly indicate where the datasets can be accessed or whether any anonymized data files are provided for replication purposes.

Our response: Thank you for this helpful suggestion. We have updated the Data Availability Statement to explicitly clarify that the anonymized dataset used for this analysis is included as a Supporting Information file (S1 Table. Database.), allowing full replication of the study. All relevant variables and coding procedures are documented for transparency and reproducibility.

8. Reviewer says: Ethical Considerations: The authors adequately describe IRB approval and informed consent. However, it would strengthen the ethical narrative to specify whether participants were compensated (monetarily or through academic credits) and confirm that participation did not influence course evaluations or academic standing.

Our response: Thank you for this important observation. We confirm that participants were not offered any monetary compensation or academic credit for their participation. Additionally, we clarify that participation was entirely voluntary and had no influence on course evaluations, grades, or academic standing. This information has been added to the Ethics Statement in the Materials and Methods section to strengthen the ethical transparency of the study.

9. Reviewer says: Language and Formatting:

A few sections would benefit from minor editorial revisions for clarity and flow, particularly in the Methods and Discussion. For instance, "not single" could be more clearly described as "married or in a relationship."

Our response: Thank you for your helpful observation. We have reviewed the manuscript for clarity and language consistency, particularly in the Methods and Discussion sections. The phrase “not single” has been revised to “married or in a relationship,” and other minor editorial improvements have been made throughout the manuscript to enhance readability and flow.

10. Reviewer says: Future Directions:

While the authors suggest longitudinal and comparative studies in the future, it may be valuable to highlight the potential of interventions (e.g., smartphone use reduction strategies or sleep hygiene programs) that could stem from this evidence.

Our response: Thank you for this thoughtful recommendation. In response, we have expanded the Discussion section to emphasize the practical relevance of our findings. Specifically, we now highlight the potential for developing and evaluating structured interventions—such as digital well-being education, sleep hygiene programs, and cognitive-behavioral strategies—that aim to mitigate insomnia and support mental health among medical students. This addition aligns with the observed associations and reinforces the translational value of our results.

11. Reviewer says: Ethics and Integrity:

There are no apparent concerns related to research misconduct or unethical practices. The ethics approval is clearly stated (CEI-EPM-UCV-2020), and there is no indication of duplicate publication at this time. However, the authors should ensure that the current manuscript provides distinct contributions relative to the prior publication (ref [21]).

Our response: Our response: Thank you for this observation. We confirm that this manuscript is a secondary analysis of data previously collected for a different research objective, as outlined in reference [21]. The present study addresses a distinct research question by examining the association between smartphone dependence/addiction and insomnia—variables not analyzed or reported in the prior publication. We have clarified this distinction in the Study Design subsection of the Materials and Methods section, ensuring full transparency and reinforcing the originality of the current contribution. There is no duplication of results or overlap in conclusions.

If you have any comments or recommendations, we are ready to respond.

Sincerely,

Mario J. Valladares-Garrido

Escuela de Medicina Humana, Universidad Señor de Sipán, Chiclayo, Peru; vgarrido@uss.edu.pe

Attachment

Submitted filename: Response_to_Reviewers_auresp_2.pdf

pone.0329495.s006.pdf (250.5KB, pdf)

Decision Letter 2

Pavle Randjelovic

Smartphone dependence, addiction, and insomnia among medical students during the COVID-19 pandemic

PONE-D-24-56765R2

Dear Dr. Valladares-Garrido,

We’re pleased to inform you that your manuscript has been judged scientifically suitable for publication and will be formally accepted for publication once it meets all outstanding technical requirements.

Within one week, you’ll receive an e-mail detailing the required amendments. When these have been addressed, you’ll receive a formal acceptance letter and your manuscript will be scheduled for publication.

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If your institution or institutions have a press office, please notify them about your upcoming paper to help maximize its impact. If they’ll be preparing press materials, please inform our press team as soon as possible -- no later than 48 hours after receiving the formal acceptance. Your manuscript will remain under strict press embargo until 2 pm Eastern Time on the date of publication. For more information, please contact onepress@plos.org.

Kind regards,

Pavle Randjelovic, Ph.D.

Academic Editor

PLOS ONE

Additional Editor Comments (optional):

Reviewers' comments:

Reviewer's Responses to Questions

Comments to the Author

Reviewer #4: All comments have been addressed

**********

2. Is the manuscript technically sound, and do the data support the conclusions??>

Reviewer #4: Yes

**********

3. Has the statistical analysis been performed appropriately and rigorously? -->?>

Reviewer #4: Yes

**********

4. Have the authors made all data underlying the findings in their manuscript fully available??>

The PLOS Data policy

Reviewer #4: Yes

**********

5. Is the manuscript presented in an intelligible fashion and written in standard English??>

Reviewer #4: Yes

**********

Reviewer #4: The manuscript now meets the requirements for publication, as all reviewer comments have been thoroughly addressed

**********

what does this mean? ). If published, this will include your full peer review and any attached files.

If you choose “no”, your identity will remain anonymous but your review may still be made public.

Do you want your identity to be public for this peer review? For information about this choice, including consent withdrawal, please see our Privacy Policy

Reviewer #4: Yes:  Carlos Miguel Rios-Gonzalez

**********

Acceptance letter

Pavle Randjelovic

PONE-D-24-56765R2

PLOS ONE

Dear Dr. Valladares-Garrido,

I'm pleased to inform you that your manuscript has been deemed suitable for publication in PLOS ONE. Congratulations! Your manuscript is now being handed over to our production team.

At this stage, our production department will prepare your paper for publication. This includes ensuring the following:

* All references, tables, and figures are properly cited

* All relevant supporting information is included in the manuscript submission,

* There are no issues that prevent the paper from being properly typeset

You will receive further instructions from the production team, including instructions on how to review your proof when it is ready. Please keep in mind that we are working through a large volume of accepted articles, so please give us a few days to review your paper and let you know the next and final steps.

Lastly, if your institution or institutions have a press office, please let them know about your upcoming paper now to help maximize its impact. If they'll be preparing press materials, please inform our press team within the next 48 hours. Your manuscript will remain under strict press embargo until 2 pm Eastern Time on the date of publication. For more information, please contact onepress@plos.org.

If we can help with anything else, please email us at customercare@plos.org.

Thank you for submitting your work to PLOS ONE and supporting open access.

Kind regards,

PLOS ONE Editorial Office Staff

on behalf of

Dr. Pavle Randjelovic

Academic Editor

PLOS ONE

Associated Data

    This section collects any data citations, data availability statements, or supplementary materials included in this article.

    Supplementary Materials

    S1 Table. Database.

    (DTA)

    pone.0329495.s001.dta (26KB, dta)
    S1 Checklist. STROBE Statement—checklist of items that should be included in reports of observational studies.

    (PDF)

    pone.0329495.s002.pdf (138.7KB, pdf)
    Attachment

    Submitted filename: Response to Editor.pdf

    pone.0329495.s004.pdf (181.9KB, pdf)
    Attachment

    Submitted filename: PONE-D-24-56765_reviewer1.pdf

    pone.0329495.s003.pdf (1.7MB, pdf)
    Attachment

    Submitted filename: Response to Reviewers.pdf

    pone.0329495.s005.pdf (423.4KB, pdf)
    Attachment

    Submitted filename: Response_to_Reviewers_auresp_2.pdf

    pone.0329495.s006.pdf (250.5KB, pdf)

    Data Availability Statement

    All relevant data are within the paper and its Supporting Information files.


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