Table 4.
Post-transplant Alcohol Relapse Risk Scores
Risk Score | Author | Study Design, Population |
Outcome | Score Components | AUC* |
---|---|---|---|---|---|
ARRA | Rodrigue et al., 201364 | Single-center, retrospective, chronic ALD | Any alcohol use | Absence of HCC, tobacco dependence, continued alcohol use after liver disease diagnosis, low motivation for alcohol treatment, poor stress management skills, no rehabilitation relationship, limited social support, lack of nonmedical behavioral consequences, and continued engagement in social activities with alcohol present. | 0.89 |
BIS-11 SF | Umman et al., 202372 | Single-center, retrospective Alcohol-associated liver failure |
Any alcohol use | Questions that assess motor impulsiveness | 0.83 |
HALT | Satapathy et al., 202069 | Single-center, retrospective, chronic ALD and AH | Harmful alcohol use (> 3 drinks per week or medical/social harm) | Older age at LT, non-alcohol-related criminal history, pre-LT abstinence period < 6 months, > 10 drinks per day. | 0.79 |
HRAR | DiMartini et al., 200068 | Single-center, retrospective, chronic ALD | Any alcohol use | daily alcohol consumption, drinking duration, previous alcohol treatment history | Not predictive |
Penn Psychosocial Model | Deutsch-Link, et al., 202057 | Single-center, retrospective, chronic ALD | Any alcohol use | Failure to engage in an IOP despite clinician recommendation, history of relapse after initial attempt at sobriety, did not stop alcohol consumption when diagnosed with liver disease | 0.77 |
SALT | Lee et al., 201870 | Multi-center, retrospective | Sustained alcohol use with > 100 days of use | >10 drinks per day at initial hospitalization, multiple prior rehabilitation attempts, prior alcohol-related legal issues, and prior illicit substance use | 0.76 |
SIPAT | Deutsch-Link, et al., 202057 | Single-center, retrospective, chronic ALD | Any alcohol use | SIPAT score ≥21 | 0.71 |
Abbreviations: AH, alcohol-associated hepatitis; ALD, alcohol-associated liver disease; ARRA, Alcohol Relapse Risk Assessment Scale; BIS-11 SF, Barratt Impulsiveness Scale-11 Short Form, HALT - HCC – hepatocellular carcinoma, IOP – intensive outpatient program, HRAR - High-Risk Alcoholism Relapse, SALT - Sustained Alcohol Use Post-Liver Transplant, SIPAT-Stanford Integrated Psychosocial Assessment for Transplant
95% CI was not uniformly provided in the reviewed publications and has not been reported.