Table 2.
C. albicans ORFs showing greater than 3-fold change in expression in at least two population samples and ORFs with Saccharomyces cerevisiae homologues implicated in pleiotropic drug resistance
| ORF | Population sample*
|
Description | ||
|---|---|---|---|---|
| D8-330 | D12-165 | D12-330 | ||
| ADH4(2183_0001)† | 0.6 | 0.9 | 24.4 | Short-chain alcohol dehydrogenase‡ |
| ADH4(2499_0006)† | 1.1 | 1.1 | 18.4 | Short-chain alcohol dehydrogenase‡ |
| MDR1§ | 1.1 | 2.3 | 17.2 | Multidrug major facilitator transporter‡ |
| YPL88¶ | 1.9 | 12.4 | 16.4 | Putative aryl alcohol dehydrogenase‡/cell wall metabolism‖ |
| YPX98 | 1.2 | 9.6 | 15.6 | YPL88-like protein‡ |
| YPR127W | 1.0 | 2.8 | 9.5 | Similar to aryl alcohol dehydrogenase‖ |
| GRE99¶ | 1.2 | 4.7 | 8.6 | Involved in diamide tolerance and induced by osmotic stress‖ |
| YNL229C | 1.2 | 0.7 | 6.2 | Glutathione transferase-like protein‡ |
| HYR1 | 1.5 | 1.4 | 4.0 | Hyphal wall protein‡/glutathione peroxidase involved in oxidative stress‖ |
| PDR16¶ | 1.0 | 1.0 | 2.1 | Multidrug resistance‡‖/lipid synthesis‖ |
| EBP95§ | 1.0 | 1.1 | 1.8 | NADPH dehydrogenase isoform 3‖ |
| CDR2¶ | 2.4 | 0.8 | 1.3 | Multidrug ABC transporter‡ |
| 2913_0002 | 0.8 | 1.0 | 1.1 | ? |
| EBP1§ | 1.1 | 0.5 | 1.0 | Estrogen binding protein‡/NADPH dehydrogenase isoform 2‖ |
| 2866_0003 | 0.9 | 0.9 | 1.0 | ? |
| YOR49¶ | 2.2 | 0.9 | 1.0 | Putative transporter of unknown substrate‖ |
| HSP12(2148_0004)** | 1.8 | 0.5 | 0.7 | 12-kd heat-shock protein‡ |
| HSP12(2734_0007)** | 1.8 | 0.2 | 0.4 | 12-kd heat-shock protein‡ |
| HSP12(2734_0006)** | 1.7 | 0.2 | 0.4 | 12-kd heat-shock protein‡ |
Fold changes in expression of ORFs in one population sample representative of each of the three patterns of gene expression are shown here. For the complete list of 301 significantly modulated ORFs, including fold changes in all eight population samples, P values, S. cerevisiae homologues, Blast-E values, and annotation based on C. albicans (http://alces.med.umn.edu/candida/) and S. cerevisiae (http://www.proteome.com/databases/index.html), see Table 4.
The different versions of ADH4 may represent different portions of the same gene, different alleles of the same gene, or different copies of a duplicated gene.
Description based on C. albicans (http://alces.med.umn.edu/candida/).
ORFs that were significantly modulated and have S. cerevisiae homologues that are activated by YAP1 overexpression (25).
ORFs that were significantly modulated and have S. cerevisiae homologues that are activated by mutations in PDR1 and/or PDR3 (13).
Description based on S. cerevisiae (http://www.proteome.com/databases/index.html).
The different versions of HSP12 may represent different portions of the same gene, different alleles of the same gene, or different copies of a duplicated gene.