Table 5.
Expected correlations between changes in scores of PROMIS-29 and EQ-5D-5L, and results
| Hypotheses addressing relative change scores (∆) | Confirmed Yes/No: |
|
|---|---|---|
| Expected relative correlations | PROMIS-29 Anxiety ∆ correlating higher with EQ-5D-5L Anxiety / Depression ∆ than with any other EQ-5D-5L dimension ∆ | Yes |
| PROMIS-29 Depression ∆ correlating higher with EQ-5D-5L Anxiety / Depression ∆ than with any other EQ-5D-5L dimension ∆ | Yes | |
| PROMIS-29 Pain Interference ∆ correlating higher with EQ-5D-5L Pain / Discomfort ∆ than with any other EQ-5D-5L dimension ∆ | Yes | |
| PROMIS-29 Pain Intensity ∆ correlating higher with EQ-5D-5L Pain / Discomfort ∆ than with any other EQ-5D-5L dimension ∆ | Yes | |
| PROMIS-29 Social Participation ∆ correlating higher with EQ-5D-5L Usual Activities ∆ than with any other EQ-5D-5L dimension ∆ | Yes | |
|
PROMIS-29 Fatigue ∆ correlating higher with EQ-5D-5L Usual Care ∆ than with any other EQ-5D-5L dimension ∆ |
Yes | |
| PROMIS-29 Sleep Disturbance ∆ correlating higher with EQ-5D-5L Pain / Discomfort ∆ than with any other EQ-5D-5L dimension ∆. | Yes | |
| EQ-5D-5L Mobility ∆ correlating higher with PROMIS-29 Physical Function ∆ than with any other PROMIS-29 domain ∆ | Yes | |
| EQ-5D-5L Self-Care ∆ correlating higher with PROMIS-29 Physical Function ∆ than with any other PROMIS-29 domain ∆ | Yes | |
| EQ-5D-5L Usual Activities ∆ correlating higher with PROMIS-29 Physical Function ∆ than with any other PROMIS-29 domain ∆ | Yes | |
| Expected magnitude of the correlations | Hypotheses addressing change scores (∆) for the most similar constructs | Confirmed Yes/No*: |
| PROMIS-29 Physical Function ∆ will correlate ≥ 0.5 with EQ-5D-5L Mobility ∆ |
No (0.49) [0.44, 0.54] |
|
| PROMIS-29 Anxiety ∆ will correlate ≥ 0.5 with EQ-5D-5L Anxiety / Depression ∆ |
No (0.43) [0.37, 0.48] |
|
| PROMIS-29 Depression ∆ will correlate ≥ 0.5 with EQ-5D-5L Anxiety / Depression ∆ |
No (0.33) [0.27, 0.38] |
|
| PROMIS-29 Pain Interference ∆ will correlate ≥ 0.5 with EQ-5D-5L Pain / Discomfort ∆ |
No (0.42) [0.37, 0.47] |
|
| PROMIS-29 Pain Intensity ∆ will correlate ≥ 0.5 with EQ-5D-5L Pain / Discomfort ∆ |
Yes (0.50) [0.45, 0.55] |
|
| Hypotheses addressing change scores (∆) for related but dissimilar constructs | Confirmed Yes/No*: | |
| PROMIS-29 Physical Function ∆ will correlate in the interval between 0.30 and 0.50 with EQ-5D-5L Self-Care ∆ |
Yes (0.33) [0.27, 0.38] |
|
| PROMIS-29 Physical Function ∆ will correlate in the interval between 0.30 and 0.50 with EQ-5D-5L Usual Activities ∆ |
Yes (0.45) [0.40, 0.49] |
|
| PROMIS-29 Social Participation ∆ will correlate in the interval between 0.30 and 0.50 with EQ-5D-5L Usual Activities ∆ |
Yes (0.36) [0.30, 0.41] |
|
| PROMIS-29 Sleep Disturbance ∆ will correlate in the interval between 0.30 and 0.50 with EQ-5D-5L Anxiety / Depression ∆ |
No (0.19) [0.13, 0.25] |
|
| Hypotheses addressing change scores (∆) for the most unrelated constructs | Confirmed Yes/No*: | |
| PROMIS-29 Sleep Disturbance ∆ will correlate < 0.3 with EQ-5D-5L Mobility ∆ |
Yes (0.12) [0.06, 0.18] |
|
| PROMIS-29 Anxiety ∆ will correlate < 0.30 with EQ-5D-5L Mobility ∆ |
Yes (0.04) [-0.02, 0.10] |
|
| PROMIS-29 Depression ∆ will correlate < 0.30 with EQ-5D-5L Self-Care ∆ |
Yes (0.13) [0.07, 0.19] |
|
| PROMIS-29 Fatigue ∆ will correlate < 0.30 with EQ-5D-5L Self-Care ∆ |
Yes (0.11) [0.20, 0.32] |
|
| PROMIS-29 Sleep Disturbance ∆ will correlate < 0.30 with EQ-5D-5L Self-Care ∆ |
Yes (0.16) [0.10, 0.22] |
*Spearman’s rho coefficient was used to compare changes in the T-scores of each PROMIS-29 domains (or numeric rating score for Pain Intensity) with changes in each EQ-5D-5L item score. [In brackets]: 95% confidence interval. The first 10 relative correlations are based on absolute numbers, and not tested for significant difference