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. 2002 Jun 27;99(14):9340–9345. doi: 10.1073/pnas.142293699

Figure 1.

Figure 1

Response of C57BL/6, (B × S)F1, and SPRET/Ei mice to TNF. (a) Lethal response of C57BL/6 (■), (B × S)F1 (▾), and SPRET/Ei (▴) mice to increasing doses of TNF injected i.p. Lethality was monitored for 1 week (no further deaths occurred). n = 8, except for 150 μg and 200 μg where n = 2. (b) Kinetics of lethal response after injection of 150 μg TNF. ■, C57BL/6 (n = 24); ▾, (B × S)F1 (n = 13); ▴, SPRET/Ei (n = 7). (c) Induction of hypothermia after injection of 150 μg of TNF. ▪, C57BL/6 (n = 4); ▾, (B × S)F1 (n = 4); ▴, SPRET/Ei (n = 5). (d–f) IL-6, NOx, and ALT concentrations after injection of 150 μg of TNF. White bars, C57BL/6 mice (n = 5); hatched bars, (B × S)F1 mice (n = 4); black bars, SPRET/Ei mice (n = 5). *, P < 0 05, **, P < 0.01; ***, P < 0.0001 (compared with C57BL/6 mice).