Table 2.
Incidence of descriptive categories associated with genes modulated by gp120
| Descriptive term | P value |
|---|---|
| Cytokine | 8.6E-06 |
| Growth factor | 3.1E-05 |
| Ligand | 1.6E-04 |
| Inhibitor or repressor | 2.7E-04 |
| Chemokine | 3.5E-04 |
| Response to bacteria | 4.0E-04 |
| Cell motility | 5.3E-04 |
| Antiviral response protein | 1.3E-03 |
| Response to biotic stimulus | 1.3E-03 |
| Chemotaxis | 1.4E-03 |
| Stress response | 1.8E-03 |
| Cell migration/motility | 4.3E-03 |
| Defense response | 9.0E-03 |
| Viral replication | 9.7E-03 |
| Cell proliferation | 2.3E-02 |
A sam-derived list of genes modulated in both PBMCs and MDMs by gp120 was analyzed for significant association with descriptive categories that distinguish this list from the rest of the genes represented on the genechip. Descriptive categories were derived from Gene Ontology and Proteome At-A-Glance classification systems. Descriptive categories that were significantly over-represented in the list that includes all of the genes modulated by HIV envelope at all time points, were ranked by P value (one-tailed Fisher Exact test). Shown are the top ten over-represented terms and five other highly represented terms relevant to the theme of viral replication.