Figure 5.

Impaired allogeneic tumor cell rejection in CnAβ^−/− mice. (A) J558L mouse plasmacytoma cells (BALB/c background) were injected s.c. into BALB/c, wild-type, CnAβ^−/−, and CsA-treated wild-type mice so that allogeneic tumor growth could be scored 10–17 days later. (B) Model for T cell activation supports a critical role for the CnAβ gene as the major calcium-dependent transducer of lymphocyte activation, when compared with CnAα. Calcineurin activation then promotes NFATc1/c2/c3 dephosphorylation, which promotes their translocation into the nucleus, where NFAT factors interact with other response pathways to orchestrate the immune response.