Structure and sequence of the cmvIL-10/sIL-10R1 complex.
(A) Ribbon diagram of the 1:2 cmvIL-10/sIL-10R1
complex viewed perpendicular to the twofold axis of cmvIL-10.
(B) Ribbon diagram of 1:2 hIL-10/sIL-10R1 complex in
the same orientation as A. (C)
Structure-based sequence alignment of hIL-10 and cmvIL-10. α-Helices
are defined by brackets and labeled. cmvIL-10 or hIL-10 residues that
bury surface into sIL-10R1 or into their respective dimer interfaces
are marked with circles and crosses, respectively. The amount of buried
surface area is denoted by different numbers of circles or crosses with
1 > 5 Å2, 2 > 10 Å2 < 35
Å2, 3 > 35 Å2 < 60
Å2, 4 > 60 Å2 < 85
Å2, and 5 > 85 Å2.