Table 2. The specifics of the three QC sample preparation stages for Doravirine, Lamivudine, and Tenofovir Disoproxil Fumarate .
|
Plasma spiking preparations – Doravirine, Lamivudine, and Tenofovir Disoproxil Fumarate | |||||
|
Concentration of stock (µg/mL) |
Stock volume (mL) |
Plasma volume (mL) |
Final volume (mL) |
Final concentration (ng/mL) |
Details |
|
18.00 |
0.1 |
0.9 |
1 |
900 |
HQC |
|
9.50 |
0.1 |
0.9 |
1 |
480 |
MQC |
|
0.08 |
0.1 |
0.9 |
1 |
7.4 |
LQC |
HQC: High-Quality Control, MQC: Middle-Quality Control, LQC: Low-Quality Control