Table 1.

Summary table depicting the effect of treatment with BRL 52537 on plasma electrolyte homeostasis and diuresis in SD rats

Parameter		Day 0	Day 1	Day 7	Day 14
Plasma K+ mm	Control	3.99 ± 0.16	4.06 ± 0.08	4.10 ± 0.07	4.21 ± 0.16
	BRL 52 537	3.85 ± 0.08	3.65 ± 0.16	3.50 ± 0.11	3.71 ± 0.14
Plasma Na+ mM	Control	142 ± 0.42	143 ± 0.47	142 ± 0.44	142 ± 1.2
	BRL 52 537	142 ± 0.58	144 ± 1.1	149 ± 0.82 (P < 0.001)	150 ± 1.5 (P = 0.005)
K+/Cre ratio	Control	51.0 ± 2.6	50.9 ± 2.2	48.8 ± 1.6	45.4 ± 2.4
	BRL 52 537	45.2 ± 3.2	50.3 ± 3.1	54.6 ± 4.5	48.3 ± 2.6
Na+/Cre ratio	Control	33 ± 5.2	32 ± 2.0	33 ± 1.1	30 ± 1.8
	BRL 52 537	33 ± 2.0	33 ± 3.1	37 ± 3.6	29 ± 1.8
Diuresis, mL/day	Control	20 ± 1.7	17 ± 2.2	21 ± 2.8	19 ± 1.6
	BRL 52 537	21 ± 2.9	35 ± 3.1 (P < 0.001)	34 ± 3.6 (P = 0.04)	38 ± 4.5 (P = 0.007)

For all data sets, urine samples were collected for 24 h. Data are displayed as means ± SEM. Significant differences occurred between BRL 52537 treatment and controls in plasma potassium levels day 7, plasma sodium levels on days 7 and 14, diuresis rates on days 1, 7, and 14.