TABLE 2.

Glossary of Key Items for DEEC Conduct

No.	Item	Definition
1	CRC	The CRC consists of several radiologists or pathologists to provide professional image end point adjudication and set up quality control for the tissue-based clinical study. Compared with the local review processed on dispersed sites, central review usually provides uniform reader training and ongoing standard management to ensure that the adjudicated end point is accurate with minimized bias49
2	IRC	In an IRC, the radiologic or pathologic reviewers provide an end point adjudication of patient imaging or clinicopathologic measures of responses independent of on-site clinical trial investigators, involving a separate efficacy assessment among a geographically dispersed team of pathologists or radiologists48,49
3	BIRC	In a BIRC, radiology or pathology reviewers are blinded to the patient information and treatment information. The BIRC could set end point adjudication with a double-read model that the medical images are reviewed by two independent readers who are blinded to the investigator assessment, the study treatment, and some predefined clinical information47
4	SRC	The SRC consists of the sponsor clinical study team, a clinical operation representative, and the principal investigators from each active clinical site contributing patients to that cohort. The SRC performs ongoing review and adjudication of SAEs and other safety events throughout the conduct of the study48

Abbreviations: BIRC, blinded independent review committee; CRC, central review committee; DEEC, dose-escalation and expansion cohort; IRC, independent review committee; SAEs, serious adverse events; SRC, safety review committee.