Table 1.

Inclusion and exclusion criteria

Inclusion criteria	Exclusion criteria
Randomized controlled clinical trials (RCTs) or controlled clinical trials (CCTs)	Case reports, case series, retrospective studies, case–control studies…
Studies regarding implant surgery (peri-implant bone stability)	Studies regarding periodontal surgery: intrabony defects, furcation defects, and periodontal plastic surgery
Articles written in English language	Other applications of L-PRF in dentistry and medicine
Studies conducted in humans	Other growth factors such as platelet-rich plasma (PRP), plasma rich in growth factors (PRGFs), advanced platelet-rich fibrin (A-PRF), and injectable platelet-rich fibrin (I-PRF)…
Using L-PRF in implant fixture insertion	Animal studies, in vivo, in vitro
	Using L-PRF in combination with other materials