Table 4.
Included studies
| Article (year) | Study design, duration | Number of participants (implants) | Mean age ± SD | Type of surgery Implant type (dimensions) |
Groups: control: C Intervention: I |
Insertion Torque (Ncm) ± SD, Statistical Significance | L-PRF formulation | Results Mean ISQ ± SD |
|---|---|---|---|---|---|---|---|---|
| Darestani et al. [43] | RCT, 12weeks | 14 (28) | 48.93 ± 13.36 | 6 months healed bone |
C: 14 implants I: 14 implants |
25 Ncm | 2700 rpm, 12′ | SN in both groups over time |
| Alhussaini [38] | RCT, 12 weeks | 32(102) | NR ≥ 18 | 6 months healed bone |
C: 102 implants BMP—PRF - I: 102 BMP + PRF + |
NR | 3000 rpm, 12′ | SN in PRF group compared to control group |
| Torkzaban et al. [39] | RCT, 4 weeks | 10 (50) | 45.3 (NR) | 6 months healed bone Dio(4,11.5 mm) |
C: 25 implants L-PRF - I: 25 implants L-PRF + |
C: In type 2 bone, 24.50 ± 2.84 In type 3 bone 24.33 ± 3.72 Ncm I: 24.62 ± 2.47 Ncm In type 2 bone. 26.25 ± 3.77 Ncm In type 3 bone (according to the Lekholm and Zarb classification) |
400 g RCF or 2,000 rpm, 10′ Froilabo Velocity14R, Paris, France |
SN after implant placement, SS ↑ after—1 week: C: 55.99 ± 3.39 I: 59.85 ± 5.32 (P = 0.004) SS ↑ in ISQ after one months: C: 63.23 ± 4.74 I: 66.62 ± 4.77 (P = 0.015) |
| Öncü and Alaaddinoglu [40] | RCT, 4 weeks | 20 (64) | 44.2 ± 12.5 |
≥ 6 months healed bone Dentsply Ankylos®C/X(NR) |
C: 33 implants L-PRF (−) I: 31 implants L-PRF (+) |
C: 25.61 ± 11.97 I: 27.10 ± 12.83 SN P = 0.632 |
2,700 rpm 12’ PC-02, Process Ltd |
SS ↑ in ISQ values after - 1 week (C: 60.0 ± 12.2, I: 69.2 ± 10.5, P = 0.002) - 4 weeks (C: 70.4 ± 7.7, I: 77.1 ± 6.0. P = 0.001) |
| Diana et al. [41] | RCT, 1 year | 29 (41) | 39.6 ± 6.7 | NR BEGO implant systems (4.5 mm, 10 mm) |
C: No PRF, 20 implants I: PRF 21 implants |
NR | 28000 rpm 12´ |
I: t0 = 56.58 ± 18.81 t1: 60.61 ± 11.49 C: t0 = 71.32 ± 7.82 t1:70.06 ± 8.69 |
| Öncü and Alaaddinoglu [42] | RCT 12 weeks | 26 (60) | 40.2 ± 11.5 |
Immediate implant Implant socket gap < 1 mm Straumann®SLActive (4.1 mm, 12 mm) |
C: 30 implants L-PRF (−) I: 30 implants L-PRF (+) |
NR |
2,700 rpm 12’ PC-02, Process Ltd |
SS ↑ in ISQ values after: - 1 weeks (C: 48.67 ± 13.61, I: 54.36 ± 15.88, P = 0.002) - 4 weeks (C: 61.03 ± 12.02, I: 69.99 ± 11.87, P = 0.002) SN ↑ in ISQ values after: - 12 weeks 35 (C: 70.08 ± 11.2, I: 71.19 ± 10.31, P = 0.682 |
| Tabrizi et al. [3] | RCT 6 weeks | 20 (40) | 39.6 ± 6.74 | ≥ 6 months healed bone BEGO (4,5 mm, 10 mm) |
C: 20 implants L-PRF (−) I: 20 implants L-PRF (+) (10) |
NR |
2,700 rpm 12’ IntraSpin™ Intra-Lock, Boca-Raton, FL, USA |
SS ↑ in ISQ value after: - 2 Weeks (C: 58.2 ± 3.6, I: 60.6 ± 3.4, P = 0.04) - 4 weeks (C: 67.1 ± 4.3, I: 70.3 ± 3.3, P = 0.014) - 6 weeks (C: 76.1 ± 2.9, I: 78.5 ± 3.3, P = 0.027 |
NR not reported, RCT randomized controlled trial, rpm rounds per minute, SS statistically significant, SN statistically nonsignificant