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. 2005 Sep 23;1(3):e38. doi: 10.1371/journal.pgen.0010038

Figure 3. pequeño Malnutrition Is Rescued by BAC Transgenic Expressing Serpini2 Gene or Pancreatic Enzyme Diet Supplementation.

Figure 3

(A–C) Treatment of pq/pq mice (blue) pharmacologically with daily pancreatic enzyme diet supplement (purple) or genetically with BAC 150E1 transgene (green), rescues (A) size, (B) weight, and (C) animal viability in comparison to wild-type mice (black). For (B) weight measurements are averaged from n = 6 males from each genotype.

(D–G) Hematoxylin and eosin staining of pancreas sections from 8-wk-old mice. Wild-type mice (D) have normal pancreatic acinar cells present and normal pancreatic morphology while in (E) pq/pq mice there is a loss of acinar cells. In the BAC+; pq/pq mice (F), pancreas acinar cells are present. The acinar cell loss in pq/pq mice treated with enzyme supplementation (G) is the same as untreated pq/pq mice (A–C), although diet supplementation is effective in combating the effects of malnutrition. Bar represents 25 μm.