Table 4.
Effect of bicucculine (BIC) alone on responses.
| ROI | Control | 20 μM BIC | Recovery |
|---|---|---|---|
| Lateral (IR+EW) | |||
| Enhanced (d9 n = 2, d11 n = 3) | 1.00 | 1.30 ± 0.32 (n = 15)* | 1.04 ± 0.12 |
| Diminished (d11 n = 1) | 1.00 | 0.58 ± 0.01 (n = 3) | 1.02 ± 0.21 |
| Aggregate (d9 n = 2, d11 n = 4) | 1.00 | 1.18 ± 0.32 (n = 18) | 1.04 ± 0.13 |
| Medial (MR+IO) | |||
| Enhanced (d9 n = 2, d11 n = 2) | 1.00 | 1.39 ± 0.11 (n = 12)* | 0.99 ± 0.14 |
| Diminished (d11 n = 2) | 1.00 | 0.44 ± 0.23 (n = 6) | 0.94 ± 0.12 |
| Aggregate (d9 n = 2, d11 n = 4) | 1.00 | 1.07 ± 0.48 (n = 18) | 0.97 ± 0.13 |
All values are normalized to control values. Three exposures and recordings were made in each preparation. Values thus represent the averages and standard deviations of 3x the indicated number of preparations. Differences between before and after exposure to BIC were not significant (p < 0.1) when both enhanced and diminished responses were included (aggregate response), but reached p < 0.005 (*) when only enhanced responses were included (Wilcoxon signed rank test, z= −3.41 for lateral ROI, z= −3.06 for medial ROI).