Fig 6.

(Upper) Schematic depicting the existence of different types of water molecules associated with different hydration modes (see text). Water type (A) corresponds to molecules bound to the surface. Their dynamical exchange is represented with dashed arrows, and k denotes the exchange rates, k_bf and k_fb. Water types (B and C) are quasifree and free molecules, respectively, and contribute to hydration through their rotational and/or translational motions. (Lower) Space-filling models of the protein Monellin in its native state (A) and two of the possible denatured random coiled states (B and C); only Monellin's chain B is presented for the coils.