Table 1.
Parameters used for the experimental protocol on mice, synthetic MRI generation from dog spinal cord histology for model pretraining, and dog spinal cord MRI fromVuong et al. (2017)for evaluating the accuracy of synthetic image generation.
| Sequence | TR/TE (ms) | Equivalent flip angles | Frequency offsets (Hz) | Diffusion gradient amplitudes (mT/m) | Diffusion gradient directions | / (ms) | NEX |
|---|---|---|---|---|---|---|---|
| Synthetic image generation protocol for model pretraining | |||||||
| Magnetization transfer | 421 / 3.3 |
1000°,
4000° |
1000, 2000,
4000, 6000, 10000, 22000, 30000 |
– | – | – | 1 |
| Diffusion | – | – | – |
2 gradient amplitudes
312.7, 625.5 4 G = 0 |
36 directions | 18 / 5 | 1 |
| Synthetic image generation protocol based on Vuong et al. (2017) | |||||||
| Magnetization transfer | 421 / 3.3 | 142°, 500° |
400, 800, 1000,
2200, 3000, 4000, 7000, 16000, 18000 |
– | – | – | 1 |
| Diffusion | – | – | – | 49 amplitudes 85.7 - 600 1 G = 0 |
1 direction
(1, 0, 0) |
7/3,
25/8, 35/8, 40/8 |
1 |
| Experimental protocol | |||||||
| RARE (T2w) |
(600, 800,
1000, 1500, 2200, 4000) / 6.3 |
– | – | – | – | – | 1 |
| 2D FLASH - Magnetization transfer | 421 / 3.3 |
1000°,
4000° |
1000, 2000,
4000, 6000, 10000, 22000, 30000 |
– | – | – | 1 |
| Diffusion-weighted EPI | 1050 / 56.6 | – | – |
2 gradient amplitudes
312.7, 625.5 4 G = 0 |
36 directions | 18 / 5 | 4 |