Fig. 2.

Significant network plasticity occurs in biological cultures when embodied in the game environment. (A to I) Network summary statistics of 1,024 recorded channels using the full duration of all Gameplay and Rest sessions. Using one-way t tests, we found significant differences in the number of nodes (P = 3.072e−3), number of edges (P = 8.396e−26), density (P = 1.009e−25), mean participation coefficient (pcoeff) (P = 3.400e−2), average weight (P = 8.910e−20), and modularity index (P = 4.129e−13) between Gameplay and Rest. No significant differences were found for clustering coefficient (P = 0.568), max betweenness (P = 0.890), or characteristic path length (P = 0.533).