Table 3.
Exposure levels of environmental chemicals in the Sapporo and Hokkaido cohorts
| Percentile | ||||||||
|---|---|---|---|---|---|---|---|---|
|
|
||||||||
| n | DL (range) | ＞ DL (％) | Min | 25th | 50th | 75th | Max | |
| Sapporo cohort | ||||||||
| Maternal blood | ||||||||
| Total dioxins (TEQ pg/g lipid) | 426 | n/a | n/a | 3.17 | 9.95 | 13.9 | 18.2 | 43.4 |
| Total PCBs (ng/g lipid) | 426 | n/a | n/a | 17.8 | 73.0 | 107 | 148 | 41500 |
| p,p′-DDE | 379 | 0.60 | 100 | 99.5 | 401 | 651 | 1010 | 4580 |
| PFOS (ng/mL) | 447 | 0.5 | 100 | 1.30 | 3.40 | 5.20 | 7.00 | 16.2 |
| PFOA (ng/mL) | 447 | 0.5 | 92.8 | 0.25 | 0.80 | 1.30 | 1.80 | 5.30 |
| MEHP (ng/mL) | 493 | 0.278 | 100 | 1.94 | 5.82 | 9.95 | 16.3 | 102 |
| BPA (ng/mL) | 59 | 0.04 | 76.3 | ＜DL | 0.040 | 0.057 | 0.072 | 0.419 |
| Cord blood | ||||||||
| BPA (ng/mL) | 285 | 0.04 | 68.8 | ＜DL | ＜DL | 0.051 | 0.076 | 0.217 |
| Maternal hair | ||||||||
| Me-Hg (μg/g) | 430 | n/a | 100 | 0.24 | 0.96 | 1.40 | 1.89 | 7.55 |
|
| ||||||||
| Hokkaido cohort | ||||||||
| Maternal blood | ||||||||
| PFHxS (ng/ml) | 1985 | 0.2 | 81.2 | ＜DL | 0.2 | 0.3 | 0.4 | 3.4 |
| PFHxA (ng/ml) | 1985 | 0.1 | 44.1 | ＜DL | ＜DL | ＜DL | 0.1 | 0.7 |
| PFHpA (ng/ml) | 1985 | 0.1 | 31.5 | ＜DL | ＜DL | ＜DL | 0.1 | 1 |
| PFOS (ng/ml) | 1985 | 0.3 | 100 | 0.8 | 2.6 | 3.4 | 4.7 | 17.9 |
| PFOA (ng/ml) | 1985 | 0.2 | 99.9 | ＜DL | 1.3 | 2 | 3.3 | 24.9 |
| PFNA (ng/ml) | 1985 | 0.3 | 99.9 | ＜DL | 0.9 | 1.2 | 1.6 | 13.2 |
| PFDA (ng/ml) | 1985 | 0.1 | 99.3 | ＜DL | 0.4 | 0.5 | 0.7 | 2.4 |
| PFUnDA (ng/ml) | 1985 | 0.1 | 99.6 | ＜DL | 1 | 1.4 | 1.9 | 5.9 |
| PFDoDA (ng/ml) | 1985 | 0.1 | 89.5 | ＜DL | 0.1 | 0.2 | 0.2 | 0.7 |
| PFTrDA (ng/ml) | 1985 | 0.1 | 97.4 | ＜DL | 0.2 | 0.3 | 0.4 | 1.3 |
| MnBP (ng/ml) | 2571 | (0.44-0.90) | 99.9 | 0.61 | 17.0 | 31.0 | 49.0 | 270 |
| MiBP (ng/ml) | 2571 | (0.44-0.90) | 96.9 | 0.22 | 2.60 | 4.30 | 7.30 | 36.0 |
| MBzP (ng/ml) | 2571 | (0.19-0.46) | 4.5 | ＜DL | ＜DL | ＜DL | ＜DL | 7.20 |
| MEHP (ng/ml) | 2571 | (0.31-0.48) | 91.3 | ＜DL | 0.5 | 1.20 | 7.00 | 150.0 |
| MEHHP (ng/ml) | 2571 | (0.11-0.23) | 16.2 | ＜DL | ＜DL | ＜DL | ＜DL | 3.30 |
| MECPP (ng/ml) | 2571 | (0.11-0.21) | 85.8 | ＜DL | ＜DL | 0.24 | 0.35 | 12.0 |
| cx-MiNP (ng/ml) | 2571 | (0.12-0.15) | 0.2 | ＜DL | ＜DL | ＜DL | ＜DL | 0.73 |
| BPA (ng/ml) | 1454 | (0.008-0.04) | 85.2 | ＜DL | 0.04 | 0.07 | 0.18 | 56.0 |
BPA: bisphenol A, cx-MiNP mono-carboxy-isononyl phthalate, DL: detection limit, MBzP: mono-benzyl phthalate, MECPP: mono (2-ethyl-5-carboxypentyl) phthalate, Me-Hg: methylmercury, MEHHP: mono (2-ethyl-5-hydroxyhexyl) phthalate, MEHP: mono(2-ethylhexyl)phthalate, MiBP: mono-isobutyl phthalate, MnBP: mono-n-butyl phthalate, PCB: polychlorinated biphenyl, PFDA: perfluorodecanoic acid, PFDoDA: perfluorododecanoic acid, PFHpA: perfluoroheptanoic acid, PFHxA: perfluorohexanoic acid, PFHxS: perfluorohexanesulfonic acid, PFNA: perfluorononanoic acid, PFOA: perfluorooctanoic acid, PFOS: perfluorooctanesulfonic acid, PFTrDA: perfluorotridecanoic acid, PFUnDA: perfluoroundecanoic acid, p,p′-DDE: 1-dichloro-2,2-bis(p-chlorophenyl) ethylene, TEQ: toxicity equivalency quantity. Sapporo cohort data,15) Hokkaido cohort PFAS data,22) Hokkaido cohort phthalate metabolites and BPA [unpublished data].