Table 7.
Multiple linear regression analysis for effects dioxin-like compounds in maternal blood using MDI and PDI scores for 6- and 18-month-old children in the Sapporo cohort
| 6 M MDI | 6 M PDI | 18 M MDI | 18 M PDI | |||||
|---|---|---|---|---|---|---|---|---|
| βa | t | βa | t | βa | t | βa | t | |
| Male | ||||||||
| Total PCDD | －0.10 | －0.91 | －0.24 | －2.36＊ | 0.01 | 0.12 | －0.13 | －0.89 |
| Total PCDF | －0.05 | －0.41 | －0.18 | －1.77 | －0.13 | －0.93 | －0.15 | －0.99 |
| Total PCDD/PCDF | －0.10 | －0.91 | －0.24 | －2.37＊ | 0.01 | 0.08 | －0.13 | －0.90 |
| Total non-ortho PCBs | 0.00 | 0.01 | －0.20 | －1.96＊ | －0.13 | －0.98 | －0.02 | －0.12 |
| Total mono-ortho PCBs | －0.05 | －0.48 | －0.21 | －2.16＊ | －0.10 | －0.79 | 0.03 | 0.18 |
| Total coplanar PCBs | －0.05 | －0.48 | －0.21 | －2.16＊ | －0.10 | －0.79 | 0.03 | 0.17 |
| Total dioxin | －0.05 | －0.49 | －0.22 | －2.23＊ | －0.10 | －0.79 | 0.03 | 0.18 |
| Female | ||||||||
| Total PCDD | －0.13 | －1.18 | －0.13 | －1.19 | 0.20 | 1.34 | 0.00 | 0.02 |
| Total PCDF | 0.08 | 0.69 | －0.12 | －0.99 | 0.24 | 1.55 | －0.10 | －0.59 |
| Total PCDD/PCDF | －0.13 | －1.14 | －0.13 | －1.20 | 0.20 | 1.36 | 0.00 | －0.01 |
| Total non-ortho PCBs | 0.04 | 0.35 | －0.14 | －1.29 | 0.15 | 1.02 | 0.03 | 0.22 |
| Total mono-ortho PCBs | 0.05 | 0.44 | －0.16 | －1.50 | 0.23 | 1.67 | 0.03 | 0.19 |
| Total coplanar PCB | 0.05 | 0.44 | －0.16 | －1.50 | 0.22 | 1.67 | 0.03 | 0.19 |
| Total dioxin | 0.04 | 0.38 | －0.16 | －1.53 | 0.23 | 1.69 | 0.02 | 0.16 |
MDI: Mental Development Index, PCB: polychlorinated biphenyl, PCDD: polychlorinated dibenzo-p-dioxin, PCDF: polychlorinated dibenzofuran, PDI: Psychomotor Development Index. ＊p ＜ 0.05. βa is the point increase in the developmental score per PCB and dioxin level (common logarithm) adjusted for gestational age (days), caffeine intake during pregnancy (mg/day), economic status; annual income, index of childcare environment, smoking during pregnancy, blood sampling time and fish intake during pregnancy (inshore fish and deep-sea fish).71)