Table 2.
Pharmacokinetic parameters for Bu and its metabolites in mice plasma and organs; Mean ± SD.
| Compounds | AUC [μmol.min/L] | HL [h] | Cmax [μmol/L] |
|---|---|---|---|
| Plasma | |||
| Bu | 3329.4 ± 521.4 | 4.48 ± 0.96 | 7.67 ± 0.51 |
| THT | 112.2 ± 5.4 | 3.19 ± 0.23 | 0.34 ± 0.01 |
| THT 1-oxide | 17405.4 ± 5548.2 | 1.98 ± 0.86 | 92.10 ± 13.47 |
| Sulfolane | 2707.8 ± 208.8 | 0.57 ± 0.07 | 54.45 ± 3.38 |
| 3-OH sulfolane | 12550.2 ± 3011.4 | 1.18 ± 0.36 | 100.68 ± 39.20 |
| Liver | |||
| Bu | 8826 ± 3820.8 | 19.36 ± 9.35 | 5.18 ± 0.31 |
| THT | 3955.8 ± 548.4 | 2.41 ± 0.45 | 17.24 ± 1.11 |
| THT-1-Oxide | – | – | – |
| Sulfolane | 6010.2 ± 264.6 | 0.32 ± 0.04 | 217.38 ± 29.79 |
| 3-OH Sulfolane | 112035.6 ± 196254 | 4.84 ± 186.99 | 94.73 ± 4.95 |
| Brain | |||
| Bu | 4579.8 ± 1366.2 | 3.85 ± 1.58 | 12.21 ± 1.64 |
| THT | – | – | – |
| THT-1-Oxide | 12539.4 ± 2170.8 | 1.17 ± 1.01 | 81.54 ± 5.61 |
| Sulfolane | 3925.8 ± 1255.8 | 1.06 ± 0.46 | 42.84 ± 8.43 |
| 3-OH Sulfolane | 3295.8 ± 709.8 | 0.65 ± 32.74 | 21.63 ± 2.34 |
| Kidneys | |||
| Bu | 1039.8 ± 352.8 | 1.22 ± 0.62 | 8.26 ± 1.31 |
| THT | – | – | – |
| THT-1-Oxide | 16959.6 ± 8016.6 | 2.12 ± 1.39 | 80.45 ± 17.97 |
| Sulfolane | 6063 ± 1397.4 | 0.96 ± 0.30 | 73.20 ± 10.79 |
| 3-OH Sulfolane | 3197.4 ± 832.8 | 1.11 ± 0.44 | 29.29 ± 3.44 |
AUC area under the curve, Bu busulphan, Cmax maximum plasma concentration, HL half-life, THT tetrahydrothiophene.