Table 3.

Distributions between brain and plasma for busulphan and its metabolites.

Compound	Ratio AUC Brain/AUC Plasma
Bu	1.38
THT	–
THT-1-Oxide	1.07
Sulfolane	1.45
3-OH Sulfolane	0.26

AUC area under the curve, Bu busulphan, THT tetrahydrothiophene.