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. Author manuscript; available in PMC: 2025 Aug 5.
Published in final edited form as: Crit Care Med. 2025 Jun 3;53(7):e1457–e1469. doi: 10.1097/CCM.0000000000006719

Figure 2.

Figure 2.

Force-directed graph: The biomarker correlation network was visualized using Cytoscape (33). Edges (i.e., correlations) are weighted based on the absolute value of the Spearman coefficient between connected nodes (i.e., biomarkers), with edge color indicating a positive (black) or negative (red dotted) correlation. Node color represents communities identified using the fast-greedy algorithm, weighted by the absolute value of the Spearman coefficient. Node size reflects the composite centrality metric. The layout was determined using the prefuse force-directed algorithm, based on the normalized value of edge weights. Soluble intercellular adhesion molecule-1 (sICAM-1) is highlighted with a bold edge. Ang-2 = angiopoietin-2, A1AT = α-1 antitrypsin, A2MB = α-2 macroglobulin, BDNF = brain-derived neurotrophic factor, B2MB = β-2 microglobulin, CRP = c-reactive protein, C3 = complement component 3, etoxan = eosinophil chemotactic protein, EPCR = endothelial protein C-receptor, IL-6 = interleukin-6, IL-8 = interleukin-8, IL-10 = interleukin-10, IL-18 = interleukin-18, RAGE = soluble receptor of advanced glycation end-products, MCP = monocyte chemotactic protein, MIP-1β = macrophage inflammatory protein-1β, MMP-3 = matrix metalloproteinases-3, MMP-9 = matrix metalloproteinases-9, SCF = stem cell factor, SPD = surfactant protein-D, TIMP-1 = tissue inhibitor of metalloproteinase-1, TM = thrombomodulin, TNFR-1 = tumor necrosis factor receptor-1, TSP = T-cell specific protein, VCAM-1 = vascular cell adhesion molecule-1, VEGF = vascular endothelial growth factor, vWF = von Willebrand factor.