TABLE 1.
Baseline Characteristics
| Pediatric Acute Lung Injury Cohort | Coagulation and Fibrinolysis in Pediatric Insulin Titration Trial Cohort | |||||
|---|---|---|---|---|---|---|
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| Characteristics | Survivors (n = 175) | Nonsurvivors (n = 39) | p | Survivors (n = 217) | Nonsurvivors (n = 34) | p |
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| Age (mo), median (IQR) | 47 (10–136) | 94 (30–164) | 0.15 | 75 (23–145) | 70 (20–144) | 0.74 |
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| Sex, n (%) | ||||||
| Male | 91 (52.0) | 26 (66.7) | 0.1 | 116 (53.5) | 15 (44.1) | 0.31 |
| Female | 84 (48.0) | 13 (33.3) | 101 (46.5) | 19 (55.9) | ||
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| Race, n (%) | ||||||
| Caucasian | 119 (68.0) | 26 (66.7) | 0.35 | 134 (61.8) | 23 (67.7) | 0.72 |
| African American | 15 (8.6) | 2 (5.1) | 58 (26.7) | 8 (23.5) | ||
| Asian/Pacific Islander | 13 (7.4) | 1 (2.6) | 9 (4.2) | 2 (5.9) | ||
| Other | 28 (16.0) | 10 (25.6) | 16 (7.4) | 1 (2.9) | ||
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| Significant comorbidities, n (%) | ||||||
| Cancer/bone marrow transplantation | 16 (9.1) | 19 (48.7) | < 0.001 | 9 (4.2) | 6 (17.6) | 0.002 |
| Vasopressor use | 69 (39.7) | 15 (38.5) | 0.89 | 94 (43.0) | 22 (64.7) | 0.02 |
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| Illness severity, median (IQR) | ||||||
| Baseline OIa | 9.5 (5.2–18.9) | 16.5 (8.1–28.0) | 0.028 | 8.4 (3.5–16.2) | 13.3 (3.8–36.7) | 0.12 |
| Baseline OIb | 9.7 (5.4–18.9) | 18.3 (9.1–34.3) | 0.02 | 7.8 (3.5–15.8) | 14.4 (5.3–47.7) | 0.045 |
| Pediatric Risk of Mortality score | 11 (5–18) | 17 (9–21) | 0.006 | 11 (5–17) | 15 (12–28) | 0.0007 |
| Baseline Pao2/Fio2 ratio | 150 (89–244) | 107 (76–170) | 0.04 | 177 (116–284) | 153 (60–281) | 0.11 |
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| Day 1 respiratory support, n (%) | ||||||
| Mechanical ventilation | 158 (90.3) | 34 (87.2) | 0.85 | 217 (100) | 34 (100) | |
| Oscillator | 7 (4.0) | 2 (5.1) | NA | NA | ||
| Continuous positive airway pressure or bilevel positive airway pressure | 10 (5.7) | 3 (7.7) | 0 | 0 | ||
IQR = interquartile range, NA = not applicable, OI = oxygenation index.
a
Baseline OI with nonmissing data.
b
Baseline OI including missing data by imputation.