TABLE 3.

Centrality Metrics for 33 Protein Biomarkers in Pediatric Acute Lung Injury Cohort

Marker	Degreea	Betweennessa	Closenessa	Strengtha	Eigenvectora	Compositea
Tissue inhibitor of metalloproteinase-1	1	1	1	1	0.96	0.99
Tumor necrosis factor receptor-1	0.83	0.38	0.96	0.96	1	0.83
Soluble intercellular adhesion molecule-1	0.96	0.43	0.86	0.74	0.72	0.74
Interleukin-8	0.92	0.13	0.91	0.88	0.89	0.74
β-2 microglobulin	0.88	0.11	0.89	0.83	0.86	0.72
Interleukin-18	0.88	0.16	0.85	0.77	0.8	0.69
Ferritin	0.92	0.08	0.84	0.79	0.79	0.68
Angiopoietin-2	0.96	0.18	0.83	0.67	0.61	0.65
Interleukin-6	0.92	0.22	0.82	0.66	0.63	0.65
Vascular cell adhesion molecule-1	0.83	0	0.82	0.74	0.79	0.64
Monocyte chemotactic protein	0.79	0.02	0.83	0.72	0.77	0.63
C-reactive protein	0.88	0.33	0.76	0.57	0.5	0.61
Stem cell factor	0.79	0.07	0.81	0.67	0.68	0.6
Interleukin-10	0.83	0	0.78	0.67	0.72	0.6
T-cell specific protein	0.88	0.11	0.74	0.6	0.58	0.58
Macrophage inflammatory protein-1β	0.63	0	0.77	0.56	0.65	0.52
Eosinophil chemotactic protein	0.63	0.17	0.67	0.45	0.48	0.48
Matrix metalloproteinases-3	0.71	0	0.7	0.46	0.47	0.47
Thrombomodulin	0.58	0.02	0.68	0.41	0.44	0.43
Brain-derived neurotrophic factor	0.58	0.01	0.65	0.4	0.41	0.41
Endothelial protein C-receptor	0.58	0	0.64	0.38	0.42	0.4
Haptoglobin	0.54	0.01	0.62	0.34	0.18	0.35
Complement component 3	0.42	0.18	0.6	0.33	0.12	0.33
von Willebrand factor	0.46	0.08	0.62	0.26	0.22	0.33
Factor VII	0.33	0.19	0.63	0.22	0.13	0.3
α-1 antitrypsin	0.38	0.06	0.58	0.26	0.11	0.28
Fibrinogen	0.29	0.06	0.55	0.23	0.06	0.24
Soluble receptor of advanced glycation end-products	0.29	0	0.54	0.16	0.16	0.24
Vitamin-D protein	0.33	0	0.51	0.23	0.07	0.23
α-2 macroglobulin	0.25	0	0.52	0.16	0.06	0.2
Vascular endothelial growth factor	0.21	0.05	0.49	0.13	0.05	0.19
Surfactant protein-D	0.21	0	0.5	0.11	0.09	0.18
Matrix metalloproteinases-9	0.17	0	0.42	0.08	0.05	0.14

^aScaled values between 0 and 1 (values closer to 1 represent higher centrality metrics).