Figure 2. Differentially abundant metabolites in children with Confirmed versus Unlikely Tuberculosis –

(A) Principal component analysis showing the clustering of each country using the targeted analysis of 105 metabolites detected and quantified in all cohorts. (B) Volcano plot showing those metabolites that significantly differed between children with confirmed TB versus those with unlikely TB controlling for age group (<5 years of age, ≥ 5 years of age) and study site using linear regression. The y-axis indicates the -log10 p-value for each metabolite and the x-axis displays the log2 fold change between groups. A false-discovery rate (FDR)-corrected p-value of less than 0.20 was considered statistically significant as indicated by the second dashed black line. Metabolites that were significantly decreased in children with confirmed TB are labelled in dark blue while those that were significantly increased are labelled in orange.