TABLE 3.

The protective effect of taking PPIs in preventing GIB during the use of selected anticoagulants (Bang et al., 2020).

Anticoagulant	Comorbidities or concomitant factors	Prevention of GIB by PPI1 Yes/insignificance/no
Dicumarin	High baseline risk of gastrointestinal injury	Yes
Warfarin	Past history of GIB, old age, comorbidities, H. pylori infection, and co-administration of antiplatelet agents	Insignificance (only in one study)
Dabigatran	Past history of GIB, old age, comorbidities, H. pylori infection, and co-administration of antiplatelet agents	No

PPIs, proton pump inhibitors; GIB, gastrointestinal bleeding.