Table 2.
Loci most tightly linked to plasmacytoma-free survival using single-locus statistics
| Chromosome
|
Interval containing peak
|
LOD at peak | Closest marker
|
Position, cM
|
LOD at marker | χ2 at marker | Susceptible allele
|
Genetics
|
||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| All | Males | Females | All | Males | Females | All | Males | Females | ||||||
| 2 | D2Mit17 | 2.1 | 6.1 | 0.1 | D2Mit17 | 56.8 | 2.4 | 5.6 | 0.0 | 6.8 | 16.1 | 1.0 | BALB/c | Additive; Male only |
| 4 | D4Mit101–D4Mit236 | 3.9 | 5.2 | 2.3 | D4Mit236 | 16.4 | 3.6 | 3.2 | 1.6 | 10.0 | 12.3 | 5.9 | BALB/c | Additive |
| 11 | D11Mit208–D11Mit39 | 5.5 | 2.2 | 4.3 | D11Mit39 | 44.8 | 3.2 | 1.4 | 2.4 | 5.8 | 5.9 | 1.8 | BALB/c | Dominant |
| 17 | D17Mit57–D17Mit34 | 2.6 | 0.4 | 5.6 | D17Mit57 | 1.1 | 2.2 | 0.2 | 3.8 | 3.8 | 1.3 | 6.4 | BALB/c | Additive; See text concerning females |
| D17Mit66–D17Mit87 | 4.0 | 0.6 | 4.6 | D17Mit87 | 29.5 | 4.0 | 0.0 | 4.4 | 19.9 | 5.0 | 19.6 | BALB/c | ||
| 18 | D18Mit60–D18Mit74 | 7.8 | 4.0 | 3.9 | D18Mit74 | 16.4 | 6.0 | 2.2 | 3.9 | 3.5 | 0.9 | 2.4 | C57BL/6 | Additive |
Maximal LOD scores are given, along with the LOD score at the most tightly linked marker used. For comparison, the results of log-rank tests at these markers after imputation of missing genotypes are provided. Results are given for all the mice, as well as results after stratification on the basis of sex. Comments are made as to the nature of the genetic effects of the alleles at these loci.