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. 2025 Jul 23;16:1595181. doi: 10.3389/fimmu.2025.1595181

Figure 7.

The image contains multiple panels showing data analysis results on mRNA and proteome. Panel A shows a bar graph of differences in mRNA and proteome, divided into “Up” and “Down.” Panel B presents a count comparison between mRNA and proteome. Panel C is a scatter plot of log2 fold changes with a regression line. Panel D features a Venn diagram comparing mRNA and proteome data. Panel E shows a scatter plot with correlation details. Panel F is a histogram of Pearson correlation coefficients. Panels G and H feature bar graphs comparing mRNA and protein levels under control and treatment conditions. Panel I and J present enriched gene ontology and pathway enrichment using dot plots.

Integrated transcriptomic and proteomics analysis of Metrnl stimulation on osteogenic differentiation. (A–F) Correlation analysis of transcriptomic and proteomics data. (A) Bar plot of DEGs and DEPs number distribution. (B) Counts plot of mRNA and protein. (C) Scatter plot of correlation between transcriptome and proteome data. (D) Venn diagram of mRNA and proteome integrated data. (E) Nine-quadrant chart for correlation analysis of multi-omics integrated analysis. (F) Pearson correlation analyses within genes in multi-omics data. (G) Aspn expression in mRNA and protein levels. (H) Sp7 expression in mRNA and protein levels. (I) GO enrichment association analysis of multi-omics. (J) KEGG pathway enrichment association analysis of multi-omics. *p < 0.05, **p < 0.01, ***p < 0.001.