Table 3:
Response to fulvestrant, palbociclib and erdafitinib combination according to FGFR1-4 amplification status
| All patients | FGFR1-4 amp | FGFR1-4 non-amp | |
|---|---|---|---|
| Total number of cases | 35 | 29 | 6 |
|
| |||
| Evaluable for efficacy | 31 | 27 | 4 |
| Best Overall Response | |||
| CR | 0 | 0 | 0 |
| PR | 3 (10%) | 2 (8%) | 1 (25%) |
| SD | 17 (55%) | 16 (59%) | 1 (25%) |
| PD | 11 (35%) | 9 (33%) | 2 (50%) |
| Non evaluable | 4 | 2 | 2 |
| Clinical Benefit Rate at 6 months | 23% | 22% | 25% |
| Duration of overall response range | 18-112 w | 18-39 w | 122 w |
| Median progression free survival (range) | 12 w (5-144w) | 12 w (6-55w) | 13 w (5-144w) |