Table 2.

Repurposed candidate drugs for AD identified using ESCARGOT on AlzKB. These drugs are novel repurposing candidate drugs as they have neither been used as treatments for Alzheimer’s disease nor reported in previous studies

Drug	Filtering	DrugClass	AD Genes	ATC classification (Level 1)	ATC classification (Level 2)
Epirubicin	2-hop Pathway	Anthracyclines Topoisomerase Inhibitors	IL1B, APOE	Antineoplastic and immunomodulating agents	Antineoplastic agents
Vemurafenib	2-hop Pathway	Cytochrome P450 1A2 Inhibitors P-Glycoprotein Inhibitors Protein Kinase Inhibitors	CASP3, ADAM10	Antineoplastic and immunomodulating agents	Antineoplastic agents
Vitamin A	2-hop BodyPart	Vitamin A	DPYSL2, APP PPARG, HMOX1	Sensory organs	Ophthalmologicals
Fulvestrant	2-hop BodyPart	Estrogen Receptor Antagonists Selective Estrogen Receptor Modulators	WWOX, ESR1, HMOX1	Antineoplastic and immunomodulating agents	Antineoplastic agents