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Cooption of renal glomeruli at 4 weeks. Early in tumor growth, all tumors demonstrate cooption of renal glomeruli (arrowheads) as seen by hematoxylin/eosin staining (A–D, ×20; E–F, ×10): Control (A and E), anti-VEGF antibody (B and F), VEGF-Trap LD (C and G), and VEGF-Trap HD (D and H). In control (E) and VEGF-Trap HD (H), coopted glomeruli (arrowheads) encased by tumor tissue (t) are seen adjacent to renal tissue (r).
