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. 2025 Jul 29;86:103385. doi: 10.1016/j.eclinm.2025.103385

Table 3.

Time-to-onset analysis of semaglutide-related depressive disorders signals using the Weibull distribution test in the FAERS database.

PT Time-to-onset (days)
Weibull distribution
Failure type
Scale parameter
Shape parameter
N Median (IQR) Min–Max α 95% CI β 95% CI
Depression 492 21.0 (2.0, 69.0) 0–1116 74.67 57.70–96.62 0.71 0.62–0.80 Early failure
Depression suicidal 29 0.0 (0.0, 15.5) 0–111 46.85 13.75–159.65 0.98 0.40–2.39 Random failure

Note: Text in bold signifies that the signal is categorized as an important medical events (IMEs). IMEs are developed and updated by European Medicines Agency (EMA).

IQR, Interquartile Range.