5. NPs Are Clinically Used in Brain Tumor Treatment .
| national clinical trial number | tumor type | nanoparticle/nanodelivery system |
|---|---|---|
| NCT02340156 | GBM | liposomes + temozolomide (TMZ) + SGT-53 |
| NCT01906385 | liposomes + rhenium 186 | |
| NCT02861222 | refractory nonbrainstem malignant glioma | liposomes + doxorubicin (DOX) |
| NCT00019630 | refractory solid tumors | liposomes + HCL+ DOX |
| NCT01848652 | relapsed and refractory primary CNS lymphoma | liposomes + PEG + DOX |
| NCT03328884 | brain metastases | liposomes + irinotecan (CPT-11) |
| NCT03086616 | diffuse intrinsic pontine glioma | convection-enhanced delivery of liposomes + irinotecan |
| NCT03818386 | brain metastases | gadolinium-based NP (AGuIX) |
| NCT04881032 | GBM | AGuIX + TMZ |
| NCT03020017 | gold NPs + NU-0129 | |
| NCT03463265 | albumin-based NPs + rapamycin | |
| NCT03250520 | brainstem glioma | platinum acetylacetonate + titanfia (NPt-Ca) |
a
AGuIX: Gadolinium-based nanoparticle.