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. 2025 Aug 9;15:29174. doi: 10.1038/s41598-025-12082-8

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© The Author(s) 2025

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Floxing of PAK1 protects against AOM/DSS tumorigenesis A. Representative colonoscopy images from colonoscopy performed after the 3rd cycle of DSS. B. Representative histological images of swiss-rolled colons, with tumors outlined in blue C. Tumor incidence, multiplicity, total tumor burden, and mean tumor size. ** p ≤ 0.01, *** ≤ 0.001 WT (n=6), PAK1KO (n=9), PAK1flVilcre (n=11), PAK1fl (n=10).