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. Author manuscript; available in PMC: 2026 Feb 10.
Published in final edited form as: Dev Neurosci. 2025 Feb 10;47(6):458–467. doi: 10.1159/000544063

Fig. 1.

Fig. 1.

Impact of neonatal hypoxic-ischemic (HI) injury and genotype on lesion volume by sex. Post-natal day 9–11 mice underwent unilateral carotid artery ligation followed by exposure to 8% oxygen for 25 min. Lesion volume was calculated as a percent loss vs. the contralateral side. Data were transformed by aligned rank test and then analyzed by two-way ANOVA with post-hoc Tukey’s test. Visualized data is before transformation. A) Hemispheric lesion volume in males after HI vs. sham by genotype. B) Hemispheric lesion volume in females after HI vs sham by genotype. C) Hippocampal lesion volume in males after HI vs sham by genotype. D) Hippocampal lesion volume in females after HI vs sham by genotype. NS=non-significant, *= P<0.05, **=P<0.01, ***= P<0.001, ****= P<0.0001. WT = wild-type; Het = heterozygote; KO = knockout; HI = hypoxia-ischemia; NS = non-significant.