Fig. 3.

Correlation between lesion volume and Iba-1+ cell counts across injured mice. Curve was identified by third order polynomial fit. A) Male hemispheric lesion volume vs. Iba-1+ counts. B) Male hippocampal lesion volume vs Iba-1+ counts. C) Female hemispheric lesion volume vs. Iba-1+ counts. D) Female hippocampal lesion volume vs. Iba-1+ counts. Black dots represent GDF-15 KO mice, dark gray represent GDF-15 heterozygote mice and light gray represent WT mice. Iba-1 = ionized calcium-binding adaptor molecule.