Figure 3. Transient increase in suprathreshold CT intrinsic excitability 1 day after NE.

(A) Average CT input resistance (R_input) 1d and 7d after SE (black) or NE (red) (1d SE: 22 cells/8 mice; 1d NE: 23 cells/5 mice; 7d SE: 23 cells/6 mice; 7d NE: 21 cells/4 mice).

(B) Average CT resting membrane potential (V_rest) 1d and 7d after SE (black) or NE (red) (1d SE: 22 cells/8 mice; 1d NE: 23 cells/5 mice; 7d SE: 23 cells/6 mice; 7d NE: 21 cells/4 mice).

(C) Average CT AP width 1d and 7d after SE (black) or NE (red) (1d SE: 21 cells/8 mice; 1d NE: 21 cells/5 mice; 7d SE: 23 cells/6 mice; 7d NE: 21 cells/4 mice).

(D) Average CT AP threshold of 1d and 7d after SE (black) or NE (red) (1d SE: 21 cells/8 mice; 1d NE: 19 cells/5 mice; 7d SE: 23 cells/6 mice; 7d NE: 21 cells/4 mice).

(E₁, E₂, G₁, G₂) Representative traces of CT firing in response to depolarizing current (50, 100, 200 pA current injections), 1d SE (E₁) vs. 1d NE (E₂); and 7d SE (G₁) vs. 7d NE (G₂).

(F, H) Average firing frequency as a function of injected current amplitude, 1d SE vs. 1d NE (F), and 7d SE vs. 7d NE (H). Current injections from 25 to 250 pA with an increment of 25 pA (1d SE: 21 cells/8 mice; 1d NE: 21 cells/5 mice; 7d SE: 23 cells/6 mice; 7d NE: 21 cells/4 mice). Asterisks indicate significant differences (**p<0.01, two-way ANOVA and Bonferroni correction for multiple comparisons).

Detailed statistical values are listed in Table 1.