Figure 6. Changes in CT sound response responses persist 7 days after NE.

(A) Example two-photon field of view from CTs imaged before and after exposure.

(B) Average responses to pure tones across all CTs in SE mice (−1d: n=507 neurons; 1d: n=460 neurons; 7d: n=432 neurons). Asterisks indicate significant pairwise differences.

(C) Same as (A) for NE mice (−1d: n=713 neurons; 1d: n=638 neurons; 7d: n=646 neurons). Asterisks indicate significant pairwise differences.

(D) Tuning curves aligned to best frequency (BF) in SE mice.

(E) Same as (D) for NE mice. Asterisks indicate significant pairwise differences (*p<0.05, Bonferroni corrected for multiple comparisons).

(F) Change in BF of matched cells in SE (black) and NE (red) mice (1d SE: n=40 neurons; 1d NE: n=36 neurons; 7d SE: n=35 neurons; 7d NE: n=40 neurons).

(G) Accuracy of a multinomial logistic regression classifier trained to decode the frequency of pure tones at 80 dB SPL. Dashed line represents chance level. Error bars represent standard deviation of decoding iterations.

(H) Average responses to white noise bursts at different intensities across all ETs in SE mice (−1d: n=438 neurons; 1d: n=460 neurons; 7d: n=411 neurons). Asterisks indicate significant pairwise differences (Bonferroni corrected for multiple comparisons).

(I) Same as (H) in NE mice (−1d: n=636 neurons; 1d: n=559 neurons; 7d: n=587 neurons). Asterisks indicate significant pairwise differences (Bonferroni corrected for multiple comparisons).

(J) Change in intensity thresholds across days in SE (black) and NE (red) mice (1d SE: n=27 neurons; 1d NE: n=31 neurons; 7d SE: n=29 neurons; 7d NE: n=25 neurons). Asterisks indicate significant pairwise differences (**p<0.01, ***p<0.001, Bonferroni corrected for multiple comparisons).

(K) Accuracy of a multinomial logistic regression trained to decode sound intensity. Dashed line represents chance level. Error bars represent standard deviation of decoding iterations.

Detailed statistical values are listed in Table 1.