TABLE 1.

Agreement between EUCAST and CLSI MICs for Candida spp. in six laboratories^a

Fungus (no. of values)	Antifungal agent	% Agreement between:		% Interlaboratory agreement for:
		E and N at 24 h	E and N at 48 h	E	N
C. albicans (90)	Fluconazole	92	92	94	97
	Itraconazole	84	80	93	81
	Posaconazole	89	85	91	92
	Voriconazole	90	87	94	90
C. dubliniensis (58)	Fluconazole	98	98	95	95
	Itraconazole	95	92	98	93
	Posaconazole	93	90	98	97
	Voriconazole	98	98	98	100
C. glabrata (42)	Fluconazole	92	81	95	98
	Itraconazole	90	77	86	93
	Posaconazole	90	86	88	95
	Voriconazole	92	83	90	86
C. guilliermondii (30)	Fluconazole	92	90	97	93
	Itraconazole	90	82	96	97
	Posaconazole	95	100	96	97
	Voriconazole	100	100	100	97
C. krusei (60)	Fluconazole	97	97	93	100
	Itraconazole	90	86	88	100
	Posaconazole	88	84	90	98
	Voriconazole	93	92	85	95
C. lusitaniae (53)	Fluconazole	98	98	98	100
	Itraconazole	93	89	96	100
	Posaconazole	95	93	100	98
	Voriconazole	98	98	98	100
C. parapsilosis (60)	Fluconazole	98	98	98	97
	Itraconazole	94	94	94	98
	Posaconazole	96	98	98	100
	Voriconazole	100	100	95	97
C. tropicalis (28)	Fluconazole	93	93	89	90
	Itraconazole	92	67	96	100
	Posaconazole	83	79	96	100
	Voriconazole	89	89	89	97
All organisms (421)	Fluconazole	95	94	95	97
	Itraconazole	90	85	93	93
	Posaconazole	91	90	92	96
	Voriconazole	94	92	93	95

^aPercent agreements of MICs between the methods within a 3-dilution range (e.g., 0.25, 0.5, and 1 μg/ml) in six laboratories, regardless of categorization, and agreements of MIC results by each method among the six centers are given. N, CLSI reference method for yeasts (M27-A2 document); E, EUCAST method (7.1 document). CLSI and EUCAST broth microdilution methods were performed according to their respective testing guidelines.