TABLE 4.
Fluconazole, itraconazole, posaconazole, and voriconazole EUCAST and CLSI MIC data for Candida isolatesa
| Fungus (no. of values) | Antifungal agent | MIC (μg/ml) by: |
|||||
|---|---|---|---|---|---|---|---|
| EUCAST |
CLSI M27-A2 |
||||||
| Range | MIC50 | MIC90 | Range | MIC50 | MIC90 | ||
| C. albicans (90) | Fluconazole | 0.12->64 | 8 | >64 | 0.12->64 | 16 | >64 |
| Itraconazole | 0.008-1 | 0.12 | 0.25 | 0.01-16 | 0.5 | 1 | |
| Posaconazole | 0.004-0.5 | 0.12 | 0.25 | 0.008-16 | 0.5 | 1 | |
| Voriconazole | 0.008-2 | 0.12 | 1 | 0.008-16 | 0.25 | 2 | |
| C. dubliniensis (58) | Fluconazole | 0.12-8 | 0.25 | 4 | 0.12-16 | 0.25 | 2 |
| Itraconazole | 0.008-0.06 | 0.008 | 0.03 | 0.008-0.25 | 0.06 | 0.12 | |
| Posaconazole | 0.004-0.06 | 0.008 | 0.03 | 0.004-0.12 | 0.06 | 0.06 | |
| Voriconazole | 0.008-0.06 | 0.008 | 0.03 | 0.008-0.06 | 0.008 | 0.03 | |
| C. glabrata (42) | Fluconazole | 0.12-64 | 2 | 32 | 0.12->64 | 4 | >64 |
| Itraconazole | 0.008-4 | 0.06 | 1 | 0.01-16 | 0.25 | 2 | |
| Posaconazole | 0.008-4 | 0.12 | 1 | 0.008-4 | 0.25 | 2 | |
| Voriconazole | 0.008-8 | 0.03 | 1 | 0.008-8 | 0.12 | 4 | |
| C. guilliermondii (30) | Fluconazole | 0.12->64 | 4 | 64 | 0.25->64 | 4 | >64 |
| Itraconazole | 0.008-16 | 0.25 | 2 | 0.03-16 | 0.5 | 16 | |
| Posaconazole | 0.004-4 | 0.12 | 1 | 0.01-2 | 0.25 | 1 | |
| Voriconazole | 0.008-8 | 0.12 | 1 | 0.008-4 | 0.12 | 2 | |
| C. krusei (60) | Fluconazole | 2-64 | 16 | 32 | 8->64 | 32 | 64 |
| Itraconazole | 0.008-0.5 | 0.12 | 0.25 | 0.12-1 | 0.5 | 1 | |
| Posaconazole | 0.008-0.5 | 0.12 | 0.5 | 0.06-1 | 0.25 | 0.5 | |
| Voriconazole | 0.008-1 | 0.12 | 0.5 | 0.06-1 | 0.25 | 0.5 | |
| C. lusitaniae (53) | Fluconazole | 0.12-1 | 0.25 | 0.5 | 0.12-2 | 0.25 | 1 |
| Itraconazole | 0.008-0.25 | 0.03 | 0.06 | 0.01-0.5 | 0.12 | 0.25 | |
| Posaconazole | 0.04-0.06 | 0.008 | 0.03 | 0.004-0.25 | 0.03 | 0.06 | |
| Voriconazole | 0.008-0.01 | 0.008 | 0.01 | 0.008-0.03 | 0.008 | 0.01 | |
| C. parapsilosis (60) | Fluconazole | 0.12-4 | 1 | 2 | 0.12-8 | 1 | 4 |
| Itraconazole | 0.008-0.25 | 0.03 | 0.12 | 0.03-0.5 | 0.12 | 0.25 | |
| Posaconazole | 0.008-0.12 | 0.03 | 0.06 | 0.01-0.25 | 0.06 | 0.12 | |
| Voriconazole | 0.008-0.5 | 0.01 | 0.06 | 0.008-0.25 | 0.03 | 0.12 | |
| C. tropicalis (28) | Fluconazole | 0.12->64 | 0.5 | >64 | 0.12->64 | 1 | >64 |
| Itraconazole | 0.008-16 | 0.03 | 0.5 | 0.06-16 | 0.12 | 8 | |
| Posaconazole | 0.008-8 | 0.01 | 8 | 0.03-8 | 0.06 | 8 | |
| Voriconazole | 0.008-16 | 0.03 | 16 | 0.008-16 | 0.06 | 16 | |
| All isolates (421) | Fluconazole | 0.12->64 | 4 | 32 | 0.12->64 | 8 | 64 |
| Itraconazole | 0.008-16 | 0.12 | 0.5 | 0.008-16 | 0.25 | 4 | |
| Posaconazole | 0.004-8 | 0.06 | 1 | 0.004-8 | 0.25 | 2 | |
| Voriconazole | 0.008-16 | 0.06 | 2 | 0.008-16 | 0.12 | 4 | |
a
CLSI M27-A2 and EUCAST broth microdilution methods.