TABLE 2.
In vitro activity of itraconazole against fluconazole-resistant isolates of Candida spp.
| Organism (no. of isolates tested) | No. of resistant isolatesa | No. of isolates at MIC (μg/ml)b: |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| 0.03 | 0.06 | 0.12 | 0.25 | 0.5 | 1 | 2 | 4 | 8 | >8 | ||
| C. albicans (3,895) | 4 | 1 | 1 | 1 | 1 | ||||||
| C. glabrata (1,054) | 88 | 2 | 2 | 15 | 18 | 9 | 42 | ||||
| C. parapsilosis (1,028) | 8 | 2 | 4 | 2 | |||||||
| C. tropicalis (829) | 3 | 1 | 1 | 1 | |||||||
| C. krusei (206) | 70 | 1 | 16 | 44 | 9 | ||||||
| All Candida spp. (7,299) | 175 | 1 | 4 | 25 | 49 | 26 | 18 | 10 | 42 | ||
a
No. of isolates for which the fluconazole MIC was ≥64 μg/ml.
b
MICs for itraconazole.