TABLE 1.
Results of the Binax NOW Streptococcus pneumoniae ICT for the detection of S. pneumoniae in BAL fluid samples
| Patient clinical status | No. of BAL fluid samples | No. of positive ICT results (%) |
|---|---|---|
| Pneumococcal pneumonia diagnosed by microbiological culturea | ||
| Blood S. pneumoniae and BAL fluid ≥104 CFU/ml S. pneumoniae | 3 | 3 |
| Blood culture no growth, BAL fluid ≥104 CFU/ml S. pneumoniae | 7 | 7b |
| No blood cultures drawn, BAL fluid ≥104 CFU/ml S. pneumoniae | 6 | 6b |
| Blood S. pneumoniae and BAL fluid 1.102 CFU/ml S. pneumoniae | 1 | 1 |
| Blood S. pneumoniae and BAL fluid no growth | 3 | 2 |
| Total | 20 | 19 (95) |
| Nonpneumococcal pneumonia | ||
| Other respiratory pathogen detected or BAL fluid culture ≥104 CFU/ml, blood culture no growth of S. pneumoniae | ||
| Chlamydia pneumoniae | 1 | 1b |
| Legionella pneumophila | 2 | 0 |
| Mycoplasma pneumoniae | 3 | 0 |
| Influenza A virus | 2 | 0 |
| Respiratory syncytial virus | 4 | 0 |
| Group A hemolytic streptococcus ≥104 CFU/ml | 1 | 0 |
| Staphylococcus aureus ≥104 CFU/ml | 6 | 1b |
| Streptococcus anginosus ≥104 CFU/ml | 2 | 0 |
| Streptococcus viridans ≥104 CFU/ml | 1 | 0 |
| Enteric gram-negative rods ≥104 CFU/ml | 4 | 0 |
| Pseudomonas aeruginosa ≥104 CFU/ml | 9 | 0 |
| Staphylococcus aureus, H. influenzae, group B streptococcus >104 CFU/ml | 1 | 1 |
| Other respiratory pathogen ≥104 CFU/ml with S. pneumoniae <104 CFU/ml, blood cultures no growth of S. pneumoniae | ||
| H. influenzae ≥104 CFU/ml + S. pneumoniae 2.5 × 102 CFU/ml | 1 | 0 |
| Staphylococcus aureus ≥104 CFU/ml + S. pneumoniae 2.5 × 103 CFU/ml | 1 | 0 |
| H. influenzae ≥104 CFU/ml + S. pneumoniae 2.103 CFU/ml | 1 | 0 |
| H. influenzae ≥104 CFU/ml + S. pneumoniae 5.103 CFU/ml | 2 | 1 |
| Total | 41 | 4 (9.8) |
| Pneumonia microbiologically not confirmed | ||
| No respiratory pathogen detected and BAL fluid culture <104 CFU/ml, blood cultures no growth of S. pneumoniae | ||
| No growth of bacteria | 14 | 1 |
| Oral flora <104 CFU/ml | 15 | 1b |
| Growth of S. pneumoniae <104 CFU/ml, blood cultures no growth of S. pneumoniae | ||
| S. pneumoniae 3.102 CFU/ml | 1 | 0 |
| S. pneumoniae 1.103 CFU/ml | 1 | 1 |
| S. pneumoniae 2.103 CFU/ml | 1 | 1b |
| Staphylococcus aureus 1.103 CFU/ml + S. pneumoniae 1.103 CFU/ml | 1 | 0 |
| H. influenzae 1.103 CFU/ml + S. pneumoniae 1.103 CFU/ml | 1 | 1b |
| H. influenzae 1.103 CFU/ml, Staphylococcus aureus 1.103 CFU/ml + S. pneumoniae 2.103 CFU/ml | 1 | 1 |
| Total | 35 | 6 (17.1) |
a
S. pneumoniae was part of a mixed flora in 9 of 20 samples. The copathogens included influenza A virus, Neisseria meningitidis, Pseudomonas aeruginosa, Moraxella catarrhalis, group C hemolytic streptococci, H. influenzae, Escherichia coli, and Staphylococcus aureus (2×); all bacteria were recovered in quantities of ≥104 CFU/ml.
b
Weakly positive results.