Table 2.

Proteins with significantly higher expression in cells treated with MDS + ASS than in those treated with ECa 233.

Protein	Function	Protein expression (compared with the control)
		ECa	MDS + ASS
CAMK2A (calcium/calmodulin-dependent protein kinase II alpha)	- A multifunctional serine/threonine kinase highly expressed in neurons48 - Involved in neurotransmitter synthesis, synaptic organization, synaptic plasticity, and LTP48	↔	↑↑↑
NDUFA11 (NADH: ubiquinone oxidoreductase subunit A11)	- A subunit of mitochondrial complex I49	↑	↑↑↑↑
PRKAA1 (protein kinase AMP-activated catalytic subunit alpha 1)	- A catalytic subunit of AMP-activated protein kinase (AMPK); promotes gastric cancer cell proliferation via JNK1 and Akt pathways21 - AMPK senses cellular energy status, maintains homeostasis, and enhances mitochondrial respiration during synaptic transmission50	↓↓↓	↑
SEH1L (SEH1-like nucleoporin)	- A component of nuclear pore complexes51 - Important for oligodendrocyte proliferation and myelination51 - Plays a key role in neuronal development and neurogenesis in mice52	↑↑	↑↑↑↑