TABLE 1.
Characteristics of the six participating centers, rate of fungemia, and characteristics of the fungal bloodstream isolates recovered in the period from May 2003 to April 2004a
| Parameter | County of Copenhagen | County of Funen | County of Aarhus | County of North Jutland | Rigshospitaletb | Hvidovre and Copenhagen City hospitals | All centers |
|---|---|---|---|---|---|---|---|
| Characteristics of participating centers | |||||||
| No. of hospitals (university/district) | 4 (3/1) | 9 (1/8) | 8 (3/5) | 7 (1/6) | 1 (1/0) | 5 (1/4) | 34 (10/24) |
| Population served in the catchment area | 600,000 | 475,000 | 640,000 | 495,000 | 70,000 | 520,000 | 2,800,000 |
| No. of discharges in 2003 | 133,000 | 97,430 | 131,000 | 95,402 | 62,500 | 109,000 | 628,332 |
| Blood culture system | BacTec | BacTec | BacT/ALERT | BacT/ALERT | BacTec | BacT/ALERT | |
| No. of bottles per blood culture (days of culture) | 4 (5) | 2 (6) | 2 (6) | 3 (7) | 2 (7) | 2 (6) | |
| Rates of fungemia | |||||||
| Fungal BSI (%) | 1.8 | 3.6 | 2.4 | 4.3c | 5.1 | 2.7 | 3.1 |
| No. of fungal infections per 1,000 discharges | 0.29 | 0.55 | 0.41 | 0.52 | 1.26 | 0.41 | 0.49 |
| Species distributionj | |||||||
| C. albicans | 26 (72) | 34 (72) | 35 (63) | 35 (60) | 38 (58) | 25 (57) | 193 (63) |
| C. glabrata | 3 (8) | 8 (17) | 10 (18) | 18 (31) | 10 (15) | 14 (32) | 63 (20) |
| C. tropicalis | 4 (11) | 1 (2) | 3 (5) | 3 (7) | 11 (4) | ||
| C. parapsilosis | 1 (3) | 2 (4) | 3 (5) | 4 (6) | 1 (2) | 11 (4) | |
| C. krusei | 4 (7) | 5 (8) | 9 (3) | ||||
| Candida spp.d | 1 (3) | 1 (2) | 3 (5) | 1 (2) | 5 (8) | 1 (2) | 12 (4) |
| Other generae | 1 (3) | 2 (4) | 1 (2) | 3 (5) | 1 (2) | 8 (3) | |
| Total | 36 | 47 | 56 | 58 | 65 | 45 | 307 |
| Reduced azole susceptibility among Candida spp. | |||||||
| Genuine SDD or R Candida spp.f | 3 (8) | 8 (17) | 14 (25) | 18 (31) | 15 (23) | 14 (32) | 72 (23) |
| Acquired SDD or R Candida spp.g | C. albicans | C. albicans, C. albicans, C. albicans, C. albicans | C. guilliermondii, C. albicans | C. parapsilosis, C. parapsilosish | C. tropicalis, C. guillermondiii | 11 (4) |
Centers were ranked according to the proportion of C. albicans isolates.
Rigshospitalet, the university hospital of Copenhagen.
Only significant positive blood culture findings are included in the BSI calculation in the County of North Jutland, making the percentage of fungal BSI seem higher.
Three C. famata isolates, two of each of the species C. guilliermondii, C. kefyr, C. holmii, and C. pelliculosa, and one Candida species.
Two isolates of Saccharomyces cerevisiae and one of the following species: Cryptococcus neoformans, Rhodotorula glutinis and Rhodotorula sp., Trichosporon asahii, Geotrichum capitatum, and Fusarium sp.
C. glabrata and C. krusei. SDD, susceptible dose dependent; R, resistant. Values are numbers of isolates. Values in parentheses are percentages.
For the participating centers, each isolate with reduced susceptibility to fluconazole (MIC > 8) and/or to itraconazole (MIC > 0.125) is indicated by organism name. Highly resistant isolates with MICs of itraconazole of >16 and of fluconazole of >64 μg/ml are in boldface. For all centers, the value given is the total number of isolates, and the value in parentheses is a percentage.
Out of 50 isolates, 44 were tested.
Out of 30 isolates, 10 were tested.
Values are numbers of isolates. Values in parentheses are percentages.