Table 1.
Comparing the baseline characteristics of studied patients between the 4 groups according to stress hyperglycemia ratio (SHR) and hemoglobin-to-red blood cell distribution width ratio (HB/RDW) levels (n=345)
| Characteristic | High SHR (≥1.18) -- low HB/RDW (≤0.76) | P | |||
|---|---|---|---|---|---|
| No--No (n= 180) | No--Yes (n=53) | Yes--No (n=75) | Yes--Yes (n=37) | ||
| Age, years | |||||
| Mean ± SD | 59.49 ± 14.91 | 64.55 ± 16.59 | 62.51 ± 13.56 | 67.46 ± 16.23 | 0.011 |
| Sex | |||||
| Male | 100 (55.56) | 27 (50.94) | 42 (56.00) | 14 (37.84) | 0.241 |
| Female | 80 (44.44) | 26 (49.06) | 33 (44.00) | 23 (62.16) | |
| Comorbidities | |||||
| Smoking | 69 (38.33) | 14 (26.42) | 29 (38.67) | 11 (29.73) | 0.346 |
| Current alcohol drinking | 74 (41.11) | 18 (33.96) | 37 (49.33) | 13 (35.14) | 0.297 |
| Prior stroke | 20 (11.11) | 6 (11.32) | 6 (8.00) | 9 (24.32) | 0.109 |
| Atrial fibrillation | 41 (22.78) | 19 (35.85) | 28 (37.33) | 14 (37.84) | 0.034 |
| Myocardial infarction | 10 (5.56) | 6 (11.32) | 5 (6.67) | 8 (21.62) | 0.017 |
| Chronic heart failure | 12 (6.67) | 13 (24.53) | 6 (8.00) | 6 (16.22) | 0.002 |
| Diabetes mellitus | 39 (21.67) | 12 (22.64) | 28 (37.33) | 14 (37.84) | 0.025 |
| Hypertension | 116 (64.44) | 39 (73.58) | 59 (78.67) | 29 (78.38) | 0.081 |
| Chronic kidney disease | 17 (9.44) | 14 (26.42) | 6 (8.00) | 7 (18.92) | 0.006 |
| History of malignancy | 3 (1.67) | 2 (3.77) | 0 (0.00) | 3 (8.11) | 0.031 |
| Dyslipidemia | 77 (42.78) | 10 (18.87) | 37 (49.33) | 17 (45.95) | 0.003 |
| Preexisting dependency | |||||
| Yes (mRS 3-5) | 2 (1.11) | 5 (9.43) | 3 (4.00) | 3 (8.11) | 0.007 |
| Onset to treatment time (minutes) | |||||
| Mean ± SD | 145.36 ± 58.21 | 136.89 ± 46.52 | 133.28 ± 60.59 | 150.65 ± 58.04 | 0.304 |
| < 3 hours | 127 (70.56) | 45 (84.91) | 62 (82.67) | 22 (59.46) | 0.010 |
| 3-4.5 hours | 53 (29.44) | 8 (15.09) | 13 (17.33) | 15 (40.54) | |
| Onset to door (minutes) | |||||
| Mean ± SD | 94.48±51.36 | 82.30±37.85 | 89.97±53.91 | 107.27±57.76 | 0.178 |
| Blood pressure at admission (mmHg) | |||||
| Systolic | 156.46± 26.12 | 154.98±28.38 | 164.53±32.14 | 167.81±33.03 | 0.034 |
| Diastolic | 91.67±17.70 | 90.51±18.46 | 96.53±22.22 | 92.19±19.81 | 0.191 |
| Admitted NIHSS | |||||
| Mean ± SD | 11.17 ± 4.88 | 12.26 ± 5.76 | 14.60 ± 6.29 | 15.13 ± 5.77 | <0.001 |
| 5-15 | 143 (79.44) | 34 (64.15) | 40 (53.33) | 15 (40.54) | <0.001 |
| 16-20 | 30 (16.67) | 15 (28.30) | 16 (21.33) | 15 (40.54) | |
| >20 | 7 (3.89) | 4 (7.55) | 19 (25.33) | 7 (18.92) | |
| TOAST classification | |||||
| Large artery atherosclerosis | 33 (18.33) | 7 (13.21) | 23 (30.67) | 13 (35.14) | 0.001 |
| Cardioembolic stroke | 49 (27.22) | 22 (41.51) | 31 (41.33) | 17 (45.95) | |
| Small-vessel occlusion | 89 (49.44) | 20 (37.74) | 18 (24.00) | 7 (18.92) | |
| Stroke of other determined etiology | 4 (2.22) | 3 (5.66) | 2 (2.67) | 0 (0.00) | |
| Stroke of undetermined etiology | 5 (2.78) | 1 (1.89) | 1 (1.33) | 0 (0.00) | |
| Baseline ASPECTS | |||||
| Median (IQR) | 10 (9 - 10) | 9 (8 - 10) | 9 (7 - 10) | 8 (7 - 10) | <0.001 |
| Hospital stays (days) | |||||
| Median (IQR) | 5 (3 - 8) | 5 (4 - 11) | 5 (3 - 9) | 8 (4 - 17) | 0.021 |
| Laboratory data | |||||
| WBC (103cells/mm3) | 8.68±2.23 | 8.89±2.74 | 9.39±3.05 | 9.53± 6.27 | 0.301 |
| Platelet (103cells/mm3) | 249.68±60.61 | 249.94±71.91 | 249.84±83.81 | 252.24±125.93 | 0.230 |
| Creatinine (mg/dL) | 0.99±0.47 | 1.52±1.59 | 0.98±0.30 | 1.09±0.50 | <0.001 |
| Admission plasma glucose (mg/dL) | 123.63±53.50 | 119.59±56.56 | 165.41±69.57 | 168.35±77.27 | <0.001 |
Values are presented as mean ± standard deviation (SD), frequency (percentage), or median (interquartile range (IQR)). mRS: modified Rankin Score; NIHSS: National Institutes of Health Stroke Scale; TOAST: trial of ORG 10172 in acute stroke treatment; WBC: white blood cell; ASPECTS: Alberta Stroke Program Early CT Score.